Obesity is a chronic, progressive and relapsing disease with a rising global prevalence
associated with increased morbidity and mortality and reduced quality of life. Treatment of …

White adipose tissue is one of the largest organs of the body. It plays a key role in whole‐body
energy status and metabolism; it not only stores excess energy but also secretes various …

Obesity, a chronic state of energy overload, is characterized by adipose tissue dysfunction
that is considered to be the major driver for obesity associated metabolic complications. The …

Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

Total daily energy expenditure (“total expenditure”) reflects daily energy needs and is a
critical variable in human health and physiology, but its trajectory over the life course is poorly …

Concentrations of liver enzymes in plasma are widely used as indicators of liver disease.
We carried out a genome-wide association study in 61,089 individuals, identifying 42 loci …

Objective: Physical activity (PA) begins to decline in adolescence with a concomitant increase
in weight. We hypothesized that a vicious circle may arise between decreasing PA and …

Background: The liver, once fatty, overproduces components of the metabolic syndrome,
such as glucose and lipids. The amount of liver fat in subjects with and without the metabolic …

Pulmonary function measures reflect respiratory health and are used in the diagnosis of
chronic obstructive pulmonary disease. We tested genome-wide association with forced …

Background Muscle biopsy is the gold standard for diagnosis of mitochondrial disorders
because of the lack of sensitive biomarkers in serum. Fibroblast growth factor 21 (FGF-21) is a …