β-catenin plays an essential role in several biological events including cell fate determination,
cell proliferation, and transformation. Here we report that β-catenin is encoded by a labile …

Background The cyclin-D/CDK4,6/p16 INK4a /pRB/E2F pathway, a key regulator of the
critical G1 to S phase transition of the cell cycle, is universally disrupted in human cancer. …

A considerable number of genes that code for AU-rich mRNAs including cytokines, growth
factors, transcriptional factors, and certain receptors are involved in both chronic inflammation …

The AU-rich elements (AREs) are among the predominant cis-acting factors that exist primarily
in the 3’ untranslated region (3’-UTR) of messenger RNAs (mRNAs) and regulate mRNA …

Post‐transcriptional control of gene expression is aberrant in cancer cells. Sustained
stabilization and enhanced translation of specific mRNAs are features of tumor cells. AU ‐rich …

Here we present an updated version of the AU-Rich Element Database (ARED-Plus) that is
freely available at http://brp.kfshrc.edu.sa/ared . AREs are conserved sequence elements …

Sunitinib is an antiangiogenic therapy given as a first-line treatment for renal cell carcinoma
(RCC). While treatment improves progression-free survival, most patients relapse. We …

The adenylate uridylate-rich elements (AREs) mediate the rapid turnover of mRNAs encoding
proteins that regulate cellular growth and body response to exogenous agents such as …

… Khabar and colleagues (33) demonstrated that the anti-IFN effect of IL-8 was detectable as
… to IL-8 proviral action express CXCR1 but not CXCR2 (KSA Khabar, unpublished data; 34). …

Background Pulmonary fibrosis is one of the leading indications for lung transplantation.
The disease, which is of unknown aetiology, can be progressive, resulting in distortion of the …