Target-protein degradation is an emerging field in drug discovery and development. In
particular, the substrate-receptor proteins of the cullin–ubiquitin ligase system play a key role in …

Aims Transradial coronary intervention (TRI) introduces a trauma to the radial artery (RA),
possibly influencing quality as a bypass conduit if subsequently used. We sought to determine …

Objective To evaluate the association between endometriosis and chronic endometritis.
Methods Endometrial specimens were obtained from 71 patients, 34 with endometriosis (…

Pladienolide is a naturally occurring macrolide that binds to the SF3b complex to inhibit
mRNA splicing. It has not been fully validated whether the splicing impairment is a relevant …

Background Chronic endometritis (CE) is a continuous inflammation of uterine endometrium,
and it is usually symptomless. As CE has been thought not to affect the reproductive status …

Background & Aims: Nonalcoholic steatohepatitis (NASH) is an emerging progressive hepatic
disease and demonstrates steatosis, inflammation, and fibrosis. Insulin resistance is a …

Our understanding of the spatiotemporal regulation of cardiogenesis is hindered by the
difficulties in modeling this complex organ currently by in vitro models. Here we develop a …

Aims The widely accepted threshold of <65 μm for coronary plaque fibrous cap thickness
was derived from postmortem studies of ruptured plaques and may not be appropriate for in …

Type-2 (T2) immune responses in airway epithelial cells (AECs) classifies mild–moderate
asthma into a T2-high phenotype. We examined whether currently available clinical …

Background Effective therapies for early endometrial cancer usually involve surgical excision
and consequent infertility Therefore, new treatment approaches that preserve fertility …