Idiopathic pulmonary fibrosis (IPF) is characterized by excessive deposition of extracellular
matrix, in particular, collagens. Two IPF therapeutics, nintedanib and pirfenidone, decelerate …

Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide. One
main pathological feature of COPD is the loss of functional alveolar tissue without adequate …

Rationale: Increased abundance and stiffness of the extracellular matrix, in particular
collagens, is a hallmark of idiopathic pulmonary fibrosis (IPF). FK506-binding protein 10 (FKBP10) …

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) represent one of the
most intensively studied families of growth factors in the last four decades. PDGF signaling …

Idiopathic pulmonary fibrosis (IPF) is a fibroproliferative disease with irreversible lung function
loss and poor survival. Myeloid-derived suppressor cells (MDSC) are associated with poor …

Rationale: Patients with chronic obstructive pulmonary disease (COPD) and in particular
smokers are more susceptible to respiratory infections contributing to acute exacerbations of …

The development of chronic obstructive pulmonary disease ( COPD ) pathogenesis remains
unclear, but emerging evidence supports a crucial role for inducible bronchus‐associated …

Fibrogenic processes instigate fatal chronic diseases leading to organ failure and death.
Underlying biological processes involve induced massive deposition of extracellular matrix (…

Idiopathic pulmonary fibrosis (IPF) is a devastating and life-threatening lung disease characterised
by epithelial reprogramming and increased extracellular matrix deposition leading to …

Aberrant antioxidant activity and excessive deposition of extracellular matrix (ECM) are
hallmarks of interstitial lung diseases (ILD). It is known that oxidative stress alters the ECM, but …