Background Evidence and practice recommendations on the use of transanal total mesorectal
excision (TaTME) for rectal cancer are conflicting. Objective We aimed to summarize best …

Background Palmoplantar psoriasis (PP) represents a localized type of disease. While
controversy over its’ classification exists, a hyperkeratotic type, a pustular type and palmoplantar …

Background There are several options for the surgical management of GERD in adults.
Previous guidelines and systematic reviews have compared the effects of total fundoplication …

… If we focus on “I” and “K” components, we can see that interventions that do not include them
show larger efficacy compared to those that include them. This could be an indication that …

Background The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)
extension statement for network meta-analysis (NMA) published in 2015 promotes …

Background: Chronic diseases are a leading cause of global morbidity and mortality. In
response to this challenge, self-management interventions (SMIs) have emerged as an essential …

… Author links open overlay panel Cherifa Cheurfa a b , Sofia Tsokani c , Katerina-Maria
Kontouli c , Isabelle Boutron a d e , … Cuello, EA Akl, RA Mustafa, JJ Meerpohl, K. Thayer, et al. …

Background There is a lack of trustworthy evidence-informed guidelines on the diagnosis
and management of acute appendicitis in elderly patients. Methods We developed a rapid …

Obesity is defined as abnormal or excessive fat accumulation that presents a risk to health.
The ability to exercise is affected by adiposity, and this mechanism involves low-grade …

Background Outbreaks of norovirus gastroenteritis aboard cruise ships may affect a large
number of people, debilitate vulnerable travellers, disrupt vacations and cause economic …