Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease

…, S Zhou, K Thain, EB Cadogan, J Maltby… - American journal of …, 2012 - atsjournals.org
Rationale: Inflammation and oxidative stress are linked to the deleterious effects of cigarette
smoke in producing chronic obstructive pulmonary disease (COPD). Myeloperoxidase (MPO…

AZD3293: Pharmacokinetic and pharmacodynamic effects in healthy subjects and patients with Alzheimer's disease

…, N Ye, L Rosen, M Russell, J Maltby… - Journal of …, 2017 - content.iospress.com
AZD3293 (LY3314814) is a promising new potentially disease-modifying BACE1 (β-secretase)
inhibitor in Phase III clinical development for the treatment of Alzheimer’s disease. …

Tolerability in man following inhalation dosing of the selective TLR7 agonist, AZD8848

S Delaney, M Biffen, J Maltby, J Bell… - BMJ open …, 2016 - bmjopenrespres.bmj.com
Background Many patients with asthma have a T-helper type 2 (Th2) driven inflammation of
the lung, whereas toll-like receptor 7 (TLR7) agonists, by inducing type I interferons, inhibit …

E. coli expression and purification of human and cynomolgus IL-15

A Ward, M Anderson, RI Craggs, J Maltby… - Protein expression and …, 2009 - Elsevier
The physiological activities of Interleukin-15 (IL-15) suggest that it could be useful as an
immunomodulator to activate the innate immune system, however, the expression and …

Population pharmacokinetic and pharmacodynamic analysis of plasma Aβ40 and Aβ42 following single oral doses of the BACE1 inhibitor AZD3839 to healthy …

…, T Olsson, J Paraskos, J Maltby… - Clinical …, 2014 - Wiley Online Library
Modulating deposition of Aβ‐containing plaques in the brain may be beneficial in treating
Alzheimer's disease. β‐site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors …

Late intervention with a myeloperoxidase inhibitor prevents emphysema and small airway remodeling in the guinea pig

…, D Sin, E Cadogan, M Soars, S Bolton, J Maltby… - 2011 - Eur Respiratory Soc
Considerable evidence links both inflammation and oxidative stress to the pathogenesis of
COPD. Myeloperoxidase (MPO), a neutrophil product, plays a major role in bacterial killing …

[PDF][PDF] Introduction: integrating social and environmental archaeologies

J Morris, M Maltby - 2010 - clok.uclan.ac.uk
… The fourth chapter (Maltby) also deals with associated bone groups, but this time from …
Finally, special thanks are due to Justine Biddle for all her hard work in helping to prepare …

Animal 'ritual'killing: from remains to meanings

J Morris - The Ritual Killing and Burial of Animals: European …, 2012 - torrossa.com
… The majority of the dogs interpreted in this way are from Maltby’s investigations of the large
… The reviewer, Ellen Hambleton and Mark Maltby for provided useful comments. Justine

[PDF][PDF] Associated bone groups; one archaeologist's rubbish is another's ritual deposition

J Morris - Changing Perspectives on the first millennium BC, 2008 - researchgate.net
… I am indebted to Mark Maltby and Ellen Hambleton for their help, advice, patience and … I
would also like to thank Paul Wheeler and Sarah-Jane Hathaway for their comments, Justine

Animal Biographies in the Iron Age of Wessex: Winnall Down, UK, Revisited

J Morris - The Bioarchaeology of Ritual and Religion, 2017 - torrossa.com
… It should be noted that Maltby would not interpret the animal burials in the same way now;
the original faunal report (Maltby nd) was written in 1981 and the publication in 1985 went to …