Macrolide antibiotics are known for their efficacy in treating acute airway infections, but just
as importantly, they are also effective anti-inflammatory agents. Their anti-inflammatory …

… To determine the effects of LPS on airway goblet cell secretion, Tamaoki and colleagues 16
pretreated pathogen-free guinea pigs with single daily doses of clarithromycin, erythromycin, …

Bronchial asthma is characterized by chronic airway inflammation, which manifests clinically
as variable airway narrowing (wheezes and dyspnea) and cough. Long-standing asthma …

Alveolar macrophages (AMs) may play a critical role in cigarette smoke (CS)-related pulmonary
diseases. This study was designed to determine whether CS induces apoptosis of AMs. …

To test whether the leukotriene antagonist ONO-1078 (pranlukast) prevents asthma
exacerbations during reduction of high-dose inhaled corticosteroid, we conducted a randomized, …

Adult bronchial asthma is characterized by chronic airway inflammation, and presents
clinically with variable airway narrowing (wheezes and dyspnea) and cough. Long-standing …

The Th2 cytokines, interleukin (IL)-4 and IL-13, bind to IL-4Rα, and cause goblet cell
metaplasia/hyperplasia with increased mucin expression in vivo. However, there is not enough …

Asthma is a chronic inflammatory disease characterized by reversible airflow limitation and
airway hyperresponsiveness. Persistent inflammation in airway tissues may lead to structural …

Macrolide antibiotics possess a variety of actions other than antimicrobial activities. To
determine the effects of long-term administration of clarithromycin (CAM) on the amount and …

Neutrophils constitutively undergo apoptosis at both normal and inflamed sites: an important
process that limits the toxic potential of the neutrophil. However, the signal pathway for …