Insufficient autophagy in idiopathic pulmonary fibrosis
…, M Kawaishi, N Kamiya, J Hirano… - … of Physiology-Lung …, 2013 - journals.physiology.org
Autophagy, a process that helps maintain homeostatic balance between the synthesis,
degradation, and recycling of organelles and proteins to meet metabolic demands, plays an …
degradation, and recycling of organelles and proteins to meet metabolic demands, plays an …
Insufficient autophagy promotes bronchial epithelial cell senescence in chronic obstructive pulmonary disease
…, T Ishikawa, T Numata, M Kawaishi, J Hirano… - …, 2012 - Taylor & Francis
Tobacco smoke-induced accelerated cell senescence has been implicated in the pathogenesis
of chronic obstructive pulmonary disease (COPD). Cell senescence is accompanied by …
of chronic obstructive pulmonary disease (COPD). Cell senescence is accompanied by …
Clinical Efficacy and Safety of Nivolumab: Results of a M ulticenter, Op e n-label, Single-a rm, Japanese Phase II study in Mal i gnant Pleural Meso t helioma (MERIT)
…, T Takahashi, M Takenoyama, H Tanaka, J Hirano… - Clinical Cancer …, 2019 - AACR
Purpose: Malignant pleural mesothelioma (MPM) is a rare and aggressive malignancy with
poor prognosis. Patients with MPM who do not respond to standard first-line chemotherapy …
poor prognosis. Patients with MPM who do not respond to standard first-line chemotherapy …
Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence
…, M Kawaishi, Y Kaneko, N Kamiya, J Hirano… - The Journal of …, 2014 - journals.aai.org
Cigarette smoke (CS)–induced cellular senescence has been implicated in the pathogenesis
of chronic obstructive pulmonary disease, and SIRT6, a histone deacetylase, antagonizes …
of chronic obstructive pulmonary disease, and SIRT6, a histone deacetylase, antagonizes …
Unilateral thoracoscopic subtotal thymectomy for the treatment of stage I and II thymoma
…, M Hiramatsu, H Matsudaira, J Hirano… - European journal of …, 2010 - academic.oup.com
Objective: The purpose of this study was to determine the feasibility of thoracoscopic thymectomy
for the treatment of Masaoka stage I and II thymoma. Methods: We evaluated the short-…
for the treatment of Masaoka stage I and II thymoma. Methods: We evaluated the short-…
Involvement of creatine kinase b in cigarette smoke–induced bronchial epithelial cell senescence
…, T Numata, M Kawaishi, K Saito, J Hirano… - American journal of …, 2012 - atsjournals.org
Cigarette smoke induces damage to proteins and organelles by oxidative stress, resulting in
accelerated epithelial cell senescence in the lung, which is implicated in chronic obstructive …
accelerated epithelial cell senescence in the lung, which is implicated in chronic obstructive …
Risk factors and cancer recurrence associated with postoperative complications after thoracoscopic lobectomy for clinical stage I non‐small cell lung cancer
…, S Mori, H Asano, H Matsudaira, J Hirano… - Thoracic …, 2019 - Wiley Online Library
Background Minimally invasive thoracoscopic lobectomy is the recommended surgery for
clinical stage I non‐small cell lung cancer (NSCLC). The purpose of this study was to identify …
clinical stage I non‐small cell lung cancer (NSCLC). The purpose of this study was to identify …
Comparative study of nonbridging and bridging external fixators for unstable distal radius fractures
C Uchikura, J Hirano, F Kudo, K Satomi… - Journal of Orthopaedic …, 2004 - Springer
The purpose of this study was to compare nonbridging external fixators (group NB) with
bridging external fixators (group B) in the treatment for unstable distal radius fractures. The …
bridging external fixators (group B) in the treatment for unstable distal radius fractures. The …
Chaperone-mediated autophagy suppresses apoptosis via regulation of the unfolded protein response during chronic obstructive pulmonary disease pathogenesis
…, T Numata, S Mori, H Matsudaira, J Hirano… - The Journal of …, 2020 - journals.aai.org
Cigarette smoke (CS) induces accumulation of misfolded proteins with concomitantly
enhanced unfolded protein response (UPR). Increased apoptosis linked to UPR has been …
enhanced unfolded protein response (UPR). Increased apoptosis linked to UPR has been …
An analysis of epilepsy with chromosomal abnormalities
…, E Nakagawa, A Nitta, N Suzuki, J Hirano… - Brain and …, 2005 - Elsevier
We retrospectively reviewed the medical records of neonates with chromosomal abnormalities
and epilepsy who had been admitted to the neonatal intensive care unit (NICU) and …
and epilepsy who had been admitted to the neonatal intensive care unit (NICU) and …