Background Diabetes mellitus causes the deterioration of smooth muscle cells and interstitial
matrix proteins, including collagen. Collagen and smooth muscle cells are abundant in the …

Background Capnography may provide useful non-invasive bedside information concerning
heterogeneity in lung ventilation, ventilation–perfusion mismatching and metabolic status. …

Changes in lung mechanics are frequently inferred from intact-chest measures of total
respiratory system mechanics without consideration of the chest wall contribution. The …

In 11 isolated dog lung lobes, we studied the size distribution of recruited alveolar volumes
that become available for gas exchange during inflation from the collapsed state. Three …

During slow inflation of lung lobes, we measure a sequence of short explosive transient
sound waves called “crackles,” each consisting of an initial spike followed by ringing. The …

The aim of this study was to test the hypothesis that the mechanism of recruitment and the
lower knee of the pressure-volume curve in the normal lung are primarily determined by …

Whereas time capnography (Tcap) is routinely displayed during mechanical ventilation, the
volumetric representation (Vcap) is seldom used. We compared the diagnostic value of …

Background: Respiratory parameters in experimental animals are often characterised under
general anaesthesia. However, anaesthesia regimes may alter the functional and …

The aim of this study was to evaluate airway structure-function relations in elastase-induced
emphysema in rats. Sprague-Dawley rats were treated intratracheally with 50 IU porcine …

Although ventilator-induced lung injury (VILI) often develops after prolonged mechanical
ventilation in normal lungs, pulmonary disorders may aggravate the development of adverse …