Background MicroRNAs are non-coding RNAs that negatively regulate gene networks.
Previously, we reported that systemically delivered miR-29 mimic MRG-201 reduced fibrosis in …

To develop a systems biology model of fibrosis progression within the human lung we
performed RNA sequencing and microRNA analysis on 95 samples obtained from 10 idiopathic …

Background: PTPN11, encoding the tyrosine phosphatase SHP-2, is a key regulator of
developmental and inflammatory pathways. Mice with an alveolar specific knockout of PTPN11 …

METHODS: Samples were purified for mRNAs and further sequenced using the Ion Torrent
Proton with PI Chip (Life Technology). Reads were mapped to Human Genome using a two …

Aim: The Genomic Research in Alpha-1 Antitrypsin Deficiency and Sarcoidosis (GRADS)
study is a multi-center collaboration that aims to enroll 400 sarcoidosis and 150 A1AT patients …

Background Sarcoidosis is a multisystem granulomatous disease of unknown origin with a
variable and often unpredictable course and pattern of organ involvement. In this study we …

… Deiuliis. The content is solely the responsibility of the authors and does not necessarily
represent the official views of the National Institute Of Diabetes And Digestive And Kidney …

Thyroid hormone (TH) is critical for the maintenance of cellular homeostasis during stress
responses, but its role in lung fibrosis is unknown. Here we found that the activity and …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease associated with
increase mortality. In this study we aim to identify and validate peripheral blood mononuclear …

Background Scaling SARS-CoV-2 testing to meet demands of safe reopenings continues to
be plagued by assay costs and supply chain shortages. In response, we developed …