[PDF][PDF] Cellular and humoral functional responses after BNT162b2 mRNA vaccination differ longitudinally between naive and subjects recovered from COVID-19

…, J Valentín-Quiroga, J Avendaño-Ortiz… - Cell reports, 2022 - cell.com
We have analyzed BNT162b2 vaccine-induced immune responses in naive subjects and
individuals recovered from coronavirus disease 2019 (COVID-19), both soon after (14 days) …

[HTML][HTML] Inflammatory cytokines and organ dysfunction associate with the aberrant DNA methylome of monocytes in sepsis

…, V Toledano, L Ciudad, J Avendaño-Ortiz… - Genome medicine, 2019 - Springer
Background Sepsis, a life-threatening organ dysfunction caused by a dysregulated systemic
immune response to infection, associates with reduced responsiveness to subsequent …

Hypoxia-induced PD-L1/PD-1 crosstalk impairs T-cell function in sleep apnoea

C Cubillos-Zapata, J Avendaño-Ortiz… - European …, 2017 - Eur Respiratory Soc
Obstructive sleep apnoea (OSA) is associated with higher cancer incidence, tumour
aggressiveness and cancer mortality, as well as greater severity of infections, which have been …

Agmatine, by improving neuroplasticity markers and inducing Nrf2, prevents corticosterone-induced depressive-like behavior in mice

AE Freitas, J Egea, I Buendia, V Gómez-Rangel… - Molecular …, 2016 - Springer
Agmatine, an endogenous neuromodulator, is a potential candidate to constitute an
adjuvant/monotherapy for the management of depression. A recent study by our group …

PD-L1 overexpression during endotoxin tolerance impairs the adaptive immune response in septic patients via HIF1α

J Avendaño-Ortiz, C Maroun-Eid… - The Journal of …, 2018 - academic.oup.com
Sepsis, among other pathologies, is an endotoxin tolerance (ET)–related disease. On
admission, we classified 48 patients with sepsis into 3 subgroups according to the ex vivo …

Tumor stem cells fuse with monocytes to form highly invasive tumor-hybrid cells

…, K Montalbán-Hernández, J Avendaño-Ortiz… - …, 2020 - Taylor & Francis
The ‘cancer cell fusion’ theory is controversial due to the lack of methods available to identify
hybrid cells and to follow the phenomenon in patients. However, it seems to be one of the …

Simultaneous determination of 8 neurotransmitters and their metabolite levels in rat brain using liquid chromatography in tandem with mass spectrometry: Application …

A Wojnicz, JA Ortiz, AI Casas, AE Freitas, MG Lopez… - Clinica Chimica …, 2016 - Elsevier
Abstract Analysis of neurotransmitters and their metabolites is useful for the diagnosis of
central nervous system diseases. A liquid chromatography–tandem mass spectrometry (LC–MS/…

[HTML][HTML] Circulating extracellular vesicles promote recovery in a preclinical model of intracerebral hemorrhage

…, J Avendaño-Ortiz… - … Therapy-Nucleic Acids, 2023 - cell.com
Circulating extracellular vesicles (EVs) are proposed to participate in enhancing pathways
of recovery after stroke through paracrine signaling. To verify this hypothesis in a proof-of-…

[HTML][HTML] NOD1 splenic activation confers ferroptosis protection and reduces macrophage recruitment under pro-atherogenic conditions

…, S González-Ramos, J Avendaño-Ortiz… - Biomedicine & …, 2022 - Elsevier
The bioavailability and regulation of iron is essential for central biological functions in mammals.
The role of this element in ferroptosis and the dysregulation of its metabolism contribute …

Monocytes inhibit NK activity via TGF-β in patients with obstructive sleep apnoea

…, A Varela-Serrano, J Avendaño-Ortiz… - European …, 2017 - Eur Respiratory Soc
Obstructive sleep apnoea (OSA) is associated with cancer incidence and mortality. The
contribution of the immune system appears to be crucial; however, the potential role of …