[HTML][HTML] PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis

…, C Corey, JD Herazo-Maya, J Sembrat… - The Journal of …, 2015 - Am Soc Clin Investig
Although aging is a known risk factor for idiopathic pulmonary fibrosis (IPF), the pathogenic
mechanisms that underlie the effects of advancing age remain largely unexplained. Some …

Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis

C Morse, T Tabib, J Sembrat… - European …, 2019 - Eur Respiratory Soc
A comprehensive understanding of the changes in gene expression in cell types involved in
idiopathic pulmonary fibrosis (IPF) will shed light on the mechanisms underlying the loss of …

IPF lung fibroblasts have a senescent phenotype

…, Y Peng, H D'Cunha, J Sembrat… - … of Physiology-Lung …, 2017 - journals.physiology.org
The mechanisms of aging that are involved in the development of idiopathic pulmonary
fibrosis (IPF) are still unclear. Although it has been hypothesized that the proliferation and …

Single-cell analysis reveals fibroblast heterogeneity and myofibroblasts in systemic sclerosis-associated interstitial lung disease

…, M Bulik, T Tabib, C Morse, J Sembrat… - Annals of the …, 2019 - ard.bmj.com
Objectives Myofibroblasts are key effector cells in the extracellular matrix remodelling of
systemic sclerosis-associated interstitial lung disease (SSc-ILD); however, the diversity of …

mTORC 1 activation decreases autophagy in aging and idiopathic pulmonary fibrosis and contributes to apoptosis resistance in IPF fibroblasts

…, M Bueno, R Ramirez, D Álvarez, JC Sembrat… - Aging cell, 2016 - Wiley Online Library
Idiopathic pulmonary fibrosis ( IPF ) is a chronic, progressive, and usually lethal disease
associated with aging. However, the molecular mechanisms of the aging process that contribute …

Resequencing study confirms that host defense and cell senescence gene variants contribute to the risk of idiopathic pulmonary fibrosis

…, KF Gibson, DJ Kass, M Rojas, J Sembrat… - American journal of …, 2019 - atsjournals.org
Rationale: Several common and rare genetic variants have been associated with idiopathic
pulmonary fibrosis, a progressive fibrotic condition that is localized to the lung. Objectives: …

Inflammatory macrophage expansion in pulmonary hypertension depends upon mobilization of blood-borne monocytes

…, Y Tang, Y Zhang, A Watson, J Sembrat… - The Journal of …, 2018 - journals.aai.org
Pulmonary inflammation, which is characterized by the presence of perivascular macrophages,
has been proposed as a key pathogenic driver of pulmonary hypertension (PH), a …

[HTML][HTML] Disparate interferon signaling and shared aberrant basaloid cells in single-cell profiling of idiopathic pulmonary fibrosis and systemic sclerosis-associated …

E Valenzi, T Tabib, A Papazoglou, J Sembrat… - Frontiers in …, 2021 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) and systemic sclerosis-associated interstitial lung disease
(SSc-ILD) differ in the predominant demographics and identified genetic risk alleles of …

GDF15 is an epithelial-derived biomarker of idiopathic pulmonary fibrosis

…, S Winters, X Chen, J Sembrat… - … of Physiology-Lung …, 2019 - journals.physiology.org
Idiopathic pulmonary fibrosis (IPF) is the most common and devastating of the interstitial lung
diseases. Epithelial dysfunction is thought to play a prominent role in disease pathology, …

ATF 3 represses PINK 1 gene transcription in lung epithelial cells to control mitochondrial homeostasis

…, L Voltz, K Fiedler, B Mays, C St. Croix, J Sembrat… - Aging …, 2018 - Wiley Online Library
PINK 1 ( PTEN ‐induced putative kinase 1) is a key regulator of mitochondrial homeostasis
that is relatively depleted in aging lungs and in lung epithelial cells from patients with …