Rationale: The current hypothesis that human pulmonary alveolarization is complete by 3
years is contradicted by new evidence of alveolarization throughout adolescence in mammals. …

Rationale: Histologic data from fatal cases suggest that extreme prematurity results in
persisting alveolar damage. However, there is new evidence that human alveolarization might …

Rationale: Asthma is characterized by disease within the small airways. Several studies have
suggested that forced oscillation technique–derived resistance at 5 Hz (R5) − resistance at …

RATIONALE AND OBJECTIVES: To investigate changes in lung microstructure in healthy
adult subjects with no smoking history using diffusion-weighted 3 He MRI. MATERIALS AND …

The use of commercialised forced oscillation (FOT) devices to assess impedance in
obstructive diseases such as asthma has gained popularity. However, it has yet to be fully …

Variability of peak flow measurements has been related to clinical outcomes in asthma. We
hypothesised that the entropy, or information content, of airway impedance over short time …

In dynamic nuclear polarization (DNP), radicals such as trityl provide a source for high nuclear
spin polarization. Conversely, during the low-field transfer of hyperpolarized solids, the …

Background The multiple-breath inert gas washout parameter acinar ventilation heterogeneity
(S acin ) is thought to be a marker of acinar airway involvement but has not been validated …

Purpose To evaluate the use of spin‐tagging in conjunction with hyperpolarized gas imaging
for monitoring lung ventilation and gas diffusion. Methods and Materials Images were taken …

Over the years, several strategies have been developed for generating highly polarized
nuclear spin systems, including dynamic nuclear polarization, optical pumping, and methods …