Infections in critically ill patients are associated with persistently poor clinical outcomes. These
patients have severely altered and variable antibiotic pharmacokinetics and are infected …

EUCAST expert rules have been developed to assist clinical microbiologists and describe
actions to be taken in response to specific antimicrobial susceptibility test results. They include …

Background Antimicrobial stewardship is advocated to improve the quality of antimicrobial
use. We did a systematic review and meta-analysis to assess whether antimicrobial …

The polymyxin antibiotics colistin (polymyxin E) and polymyxin B became available in the
1950s and thus did not undergo contemporary drug development procedures. Their clinical …

Interest in the relationships between the pharmacokinetics (PK) and pharmacodynamics (PD)
of antimicrobial agents has increased over recent years. Since the appearance 2 years …

Background Colistin–carbapenem combinations are synergistic in vitro against carbapenem-resistant
Gram-negative bacteria. We aimed to test whether combination therapy improves …

… Johan W. Mouton … Mouton, Anders Österlund, Arne Rodloff, Martin Steinbakk, Pavla
Urbaskova, Alkiviadis Vatopoulos, European harmonization of MIC breakpoints for antimicrobial …

In the face of diminishing therapeutic options for the treatment of infections caused by
multidrug-resistant, Gram-negative bacteria, clinicians are increasingly using colistin and …

Over the last decades, numerous papers have appeared—and still are appearing—that
describe concentrations in tissues in an effort to predict the efficacy of an antimicrobial agent …

Scope These ESCMID guidelines address the targeted antibiotic treatment of third-generation
cephalosporin-resistant Enterobacterales (3GCephRE) and carbapenem-resistant Gram-…