Genes involved in the production of pulmonary surfactant are crucial for the development
and maintenance of healthy lungs. Germline mutations in surfactant-related genes cause a …

Background Given the phenotypic similarities between rheumatoid arthritis (RA)–associated
interstitial lung disease (ILD) (hereafter, RA-ILD) and idiopathic pulmonary fibrosis, we …

Rationale: Familial clustering of adult idiopathic interstitial pneumonias (IIP) suggests that
genetic factors might play an important role in disease development. Mutations in the gene …

Telomere maintenance dysfunction has been implicated in the pathogenesis of Idiopathic
Pulmonary Fibrosis (IPF). However, the mechanism of how telomere length is related to …

… Kazemier BSc a d , Joanne J. van der Vis BSc a b , Pieter Zanen MD, PhD a d , Matthijs
FM van Oosterhout MD, PhD c , Jan C. Grutters MD, PhD a d …

Idiopathic interstitial pneumonias (IIPs) are diffuse lung diseases of unknown cause and high
mortality. Up to 20% of patients with IIP report having one or more family members with the …

Exonic sequencing identified a family with idiopathic pulmonary fibrosis (IPF) containing a
previously unreported heterozygous mutation in POT1 p.(L259S). The family displays short …

Background and objective A common polymorphism in the MUC5B gene (rs35705950) is
associated with susceptibility to idiopathic pulmonary fibrosis ( IPF ) and familial interstitial …

Diversity in response on exposure to severe acute respiratory syndrome coronavirus 2 may
be related to the innate immune response in the elderly. The mucin MUC5B is an important …

… Solomon b , Coline HM van Moorsel c , Romain Garofoli a , Joyce S. Lee d , Fabienne
Louis-… Antoniou i , Prodromos Sidiropoulos j , Athina Trachalaki k , Joanne J. van der Vis c … …