Remarkable phenotype plasticity of epithelial cells underlies morphogenesis, epithelial
repair and tumor invasiveness. Detailed understanding of the contextual cues and molecular …

TP53 gene mutations are one of the most frequent somatic events in cancer. The IARC TP53
Database ( http://p53.iarc.fr ) is a popular resource that compiles occurrence and phenotype …

Antibiotics administered in low doses have been widely used as growth promoters in the
agricultural industry since the 1950s, yet the mechanisms for this effect are unclear. Because …

Somatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a
significant proportion of patients with myeloid malignancies. Although there are extensive …

Epithelial‐to‐mesenchymal transitions (EMTs) underlie cell plasticity required in embryonic
development and frequently observed in advanced carcinogenesis. Transforming growth …

Polycomb group proteins are critical to maintaining gene repression established during
Drosophila development. Part of this group forms the PRC2 complex containing Ez that …

Epithelial–mesenchymal transitions (EMTs) are an essential manifestation of epithelial cell
plasticity during morphogenesis, wound healing, and tumor progression. Transforming …

We have developed animal models of breast cancer that allow the direct examination of the
behavior of individual green fluorescent protein-expressing carcinoma cells in live …

T cells directed to endogenous tumor antigens are powerful mediators of tumor regression.
Recent immunotherapy advances have identified effective interventions to unleash tumor-…

Aristolochic acid, a potent human carcinogen produced by Aristolochia plants, is associated
with urothelial carcinoma of the upper urinary tract (UUC). Following metabolic activation, …