Family, twin, and adoption studies show that psychiatric diseases including bipolar disorder
(BP) and unipolar disorder (UP) have a substantial genetic component. For these illnesses, …

Most genome-wide association and fine-mapping studies to date have been conducted in
individuals of European descent, and genetic studies of populations of Hispanic/Latino and …

The application of large-scale metabolomic profiling provides new opportunities for realizing
the potential of omics-based precision medicine for asthma. By leveraging data from over …

Rationale: Severe α 1 -antitrypsin deficiency (typically PiZZ homozygosity) is associated with
a significantly increased risk of airflow obstruction and emphysema but the risk of chronic …

Bronchodilator response (BDR) is an important asthma phenotype that measures
reversibility of airway obstruction by comparing lung function (ie FEV 1 ) before and after the …

Metabolomics is the qualitative and quantitative assessment of the metabolites (small
molecules < 1.5 kDa) in body fluids. The metabolites are the downstream of the genetic …

Short‐acting β agonists (eg, albuterol) are the most commonly used medications for asthma,
a disease that affects over 300 million people in the world. Metabolomic profiling of …

Rationale: Association studies have implicated many genes in asthma pathogenesis, with
replicated associations between single-nucleotide polymorphisms (SNPs) and asthma …

Background The metabolomic signatures of short- and long-term exposure to PM 2.5 have
been reported and linked to inflammation and oxidative stress. However, little is known about …

Background Changes in cell-type composition of tissues are associated with a wide range
of diseases and environmental risk factors and may be causally implicated in disease …