Substance P (SP) can cause plasma leakage at sites of inflammation by binding to neurokinin
type 1 (NK1) receptors on the surface of endothelial cells. Internalization after ligand …

Background and objective A new taxonomic and management approach, termed treatable
traits, has been proposed for airway diseases including severe asthma. This study examined …

Fifty consecutive patients with chronic airflow obstruction who were admitted to a respiratory
unit were assessed medically and psychiatrically. A high rate of psychiatric morbidity (58%) …

Severe asthma is a high-burden disease. Real-world data on mepolizumab in patients with
severe eosinophilic asthma is needed to assess whether the data from randomised …

Background Severe asthma affects quality of life; however, its impact on workplace productivity
is poorly understood. Objective To compare workplace productivity—absenteeism and …

Wildfires are increasing and cause health effects. The immediate and ongoing health impacts
of prolonged wildfire smoke exposure in severe asthma are unknown. This longitudinal …

Cytoplasmic vesicles, resembling synaptic vesicles of efferent nerve fibers,* are a distinctive
feature of sensory nerve fibers that innervate glomus cells of the carotid body (Biscoe et al, …

Background Asthma remission has emerged as a potential treatment goal. This study
evaluated the effectiveness of two biologics (mepolizumab/omalizumab) in achieving asthma …

Background Comorbidities in severe asthma are common and contribute to disease burden.
The severe asthma phenotype and treatment response can be impacted by comorbid …

Bronchiolitis is characterized histologically by epithelial necrosis and peribronchial infiltration
of leukocytes, with a high percentage of neutrophils in the airways. We investigated the …