Objectives Familial Mediterranean fever (FMF) can be complicated by AA amyloidosis (AAA),
though it remains unclear why only some patients develop amyloidosis. We examined the …

With an estimated life-time prevalence of 15 to 17% and an incapacitating illness in 50% of
cases, depressive spectrum disorders represent a heavy public health burden. Despite …

In lung vasculature, reversible constriction of smooth muscle cells exists in response to acute
decrease in oxygen levels (hypoxia). Progressive and irreversible structural remodeling …

Smoking is a major risk factor of morbidity and mortality. It is well established that monoamine
oxidase (MAO) activity is decreased in smokers. Serotonin (5-HT), a major substrate for …

Complex interactions between the host and the gut microbiota govern intestinal homeostasis
but remain poorly understood. Here we reveal a relationship between gut microbiota and …

Purpose Pulmonary hypertension can occur in patients who have disorders associated with
altered platelet serotonin storage, including collagen vascular disease and platelet storage …

Parkinson disease (PD) is a neurodegenerative disorder characterized by a loss of
dopamine-containing neurons. Mounting evidence suggests that dopaminergic cell death is …

Melatonin is produced in the dark by the pineal gland and is a key regulator of circadian
and seasonal rhythms. A low melatonin level has been reported in individuals with autism …

The extent to which microbiota alterations define or influence the outcome of metabolic
diseases is still unclear, but the byproducts of microbiota metabolism are known to have an …

The serotonin transporter (SERT) ensures the recapture of serotonin and is the pharmacological
target of selective serotonin reuptake inhibitor (SSRI) antidepressants. We show that …