Over the last three decades, it has become clear that the role of vitamin D goes beyond the
regulation of calcium homeostasis and bone health. An important extraskeletal effect of …

Objective Both Th1 cells and Th17 cells have been recognized in rheumatoid arthritis (RA);
however, it remains unclear whether Th1 cells and/or Th17 cells are involved in driving …

GATA-2 is an essential transcription factor in the hematopoietic system that is expressed in
hematopoietic stem cells (HSCs) and progenitors. Complete deficiency of GATA-2 in the …

Objective To examine the immunologic mechanism by which 1,25‐dihydroxyvitamin D 3 (1,25[OH]
2 D 3 ) may prevent corticosteroid‐induced osteoporosis in patients with early …

It is now established that Bcl11b specifies T cell fate. Here, we show that in developing T
cells, the Bcl11b enhancer repositioned from the lamina to the nuclear interior. Our search for …

On antigen binding by the B-cell receptor (BCR), B cells up-regulate protein expression of
the key downstream signaling molecule Bruton tyrosine kinase (Btk), but the effects of Btk up-…

T helper 17 (Th17) cells are important mediators of immune responses against extracellular
bacteria and fungi, and as such play critical regulatory roles in maintaining mucosal …

The IL-17A producing T-helper-17 (Th17) cell population plays a major role in rheumatoid
arthritis (RA) pathogenesis and has gained wide interest as treatment target. IL-17A …

Th17 cells are critically involved in autoimmune disease induction and severity. Recently,
we showed that Th17 cells from patients with rheumatoid arthritis (RA) directly induced a …

Fertilization of the female gametophyte in angiosperm plants initiates a process of coordinated
development of embryo, endosperm, and seed coat that ensures the production of a …