Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …

Background— We previously reported high-throughput RNA sequencing analyses that
identified heightened expression of the chromatin architectural factor High Mobility Group AT-…

Mitochondrial dysfunction, inflammation, and mutant bone morphogenetic protein receptor 2
(BMPR2) are associated with pulmonary arterial hypertension (PAH), an incurable disease …

Rationale: Pulmonary arterial hypertension is characterized by endothelial dysfunction,
impaired bone morphogenetic protein receptor 2 (BMPR2) signaling, and increased elastase …

Rationale: Accelerated arterial stiffening is a major complication of diabetes mellitus with no
specific therapy available to date. Objective: The present study investigates the role of the …

Rationale: Maintaining endothelial cells (EC) as a monolayer in the vessel wall depends on
their metabolic state and gene expression profile, features influenced by contact with …

Rationale: Pulmonary arterial hypertension is characterized by endothelial dysregulation,
but global changes in gene expression have not been related to perturbations in function. …

Amphetamine (AMPH) or methamphetamine (METH) abuse can cause oxidative damage
and is a risk factor for diseases including pulmonary arterial hypertension (PAH). Pulmonary …

Rationale: In pulmonary arterial hypertension (PAH), endothelial dysfunction and obliterative
vascular disease are associated with DNA damage and impaired signaling of BMPR2 (…

Using proteomic approaches, we uncovered a DNA damage response (DDR) function for
peroxisome proliferator activated receptor γ (PPARγ) through its interaction with the DNA …