Crohn's disease is the result of an abnormal immune response of the gut mucosa triggered
by one or more environmental risk factors in people with predisposing gene variations, …

Crohn's disease 1 , 2 and ulcerative colitis, the two main types of chronic inflammatory
bowel disease, are multifactorial conditions of unknown aetiology. A susceptibility locus for …

CARD15/NOD2 encodes a protein involved in bacterial recognition by monocytes. Mutations
in CARD15 have recently been found in patients with Crohn disease (CD), a chronic …

In this paper, a Working Group on Gastro-Oesophageal Reflux discusses recommendations
for the first line diagnostic and therapeutic approach of gastro-oesophageal reflux disease in …

Hoyeraal-Hreidarsson syndrome represents a severe variant of dyskeratosis congenita (Zinsser-Cole-Engman
syndrome). This X-linked recessive, progressive, multisystemic disorder …

Background & Aims: Oral rehydration therapy is the only treatment recommended by the World
Health Organization in acute diarrhea in children. Antisecretory drugs available could not …

Background: Crohn’s disease is one of the principal human chronic inflammatory bowel
diseases. Although its aetiology is still unknown, its complex pathogenesis has environmental, …

Background Infliximab (IFX) is efficacious in inducing remission in severe forms of pediatric
Crohn's disease (CD). Adult studies indicate that IFX is also safe and well tolerated as …

Background & Aims Little is known about the magnitude of the risk of anal and rectal cancer
in patients with anal and/or perineal Crohn’s disease. We aimed to assess the risk of anal …

Background Immunosuppressors play a major role in maintaining remission in Crohn's
disease (CD). In patients who do not tolerate or escape therapy with azathioprine (AZA)/6-…