Reduction of hospital admissions after pulmonary rehabilitation of geriatric patients with COPD

S Blindenbach, JE Elgersma, J vd Zeijden, HJ Reesink… - 2015 - Eur Respiratory Soc
Introduction: Pulmonary rehabilitation has been proven effective in the management of
patients with Chronic Obstructive Pulmonary Disease (COPD). However, geriatric patients are …

[HTML][HTML] RHEB/mTOR hyperactivity causes cortical malformations and epileptic seizures through increased axonal connectivity

…, M de Brito van Velze, Z Gao, Y Elgersma… - PLoS …, 2021 - journals.plos.org
… The authors would like to thank Elize Haasdijk, Charlotte de Konink, Hang Le Ha, Anne
Polman, and Chi Yeung for their technical contribution and Minetta Elgersma-Hooisma for …

[PDF][PDF] Adult Camk2a gene reinstatement restores the learning and plasticity deficits of Camk2a knockout mice

…, MA Jolfaei, J Kingma, L Post, M Elgersma, Y Elgersma… - Iscience, 2022 - cell.com
With the recent findings that mutations in the gene encoding the α-subunit of calcium/calmodulin-dependent
protein kinase II (CAMK2A) causes a neurodevelopmental disorder (NDD), …

[PDF][PDF] De novo mutations in protein kinase genes CAMK2A and CAMK2B cause intellectual disability

…, PB Agrawal, S Bézieau, S Odent, Y Elgersma… - The American Journal of …, 2017 - cell.com
Calcium/calmodulin-dependent protein kinase II (CAMK2) is one of the first proteins shown
to be essential for normal learning and synaptic plasticity in mice, but its requirement for …

RHEB/mTOR-hyperactivity causing cortical malformations drives seizures through increased axonal connectivity

…, M Nellist, M de Brito van Velze, Z Gao, Y Elgersma… - bioRxiv, 2020 - biorxiv.org
… The authors would like to thank Charlotte de Konink, Hang Le Ha, Anne Polman and Chi
Yeung for their technical contribution and Minetta Elgersma-Hooisma for managing the mouse …

Bidirectional changes in excitability upon loss of both CAMK2A and CAMK2B

MJ Kool, HE Bodde, Y Elgersma, GM van Woerden - bioRxiv, 2022 - biorxiv.org
The mammalian Ca2+/calmodulin-dependent protein kinase II (CAMK2) family consists of 4
different CAMK2 genes, encoding CAMK2A, CAMK2B, CAMK2D and CAMK2G, which have …

[PDF][PDF] Adult Camk2a gene reinstatement restores the learning and plasticity deficits of Camk2a knockout mice

MF Pomme, I Rigter, Y Elgersma, G Elgersma… - pure.eur.nl
With the recent findings that mutations in the gene encoding the a-subunit of calcium/calmodulin-dependent
protein kinase II (CAMK2A) causes a neurodevelopmental disorder (NDD), …

Ube3a loss increases excitability and blunts orientation tuning in the visual cortex of Angelman syndrome model mice

…, GM van Woerden, Y Elgersma… - Journal of …, 2017 - journals.physiology.org
Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss of the maternally
inherited allele of UBE3A. Ube3a STOP/p+ mice recapitulate major features of AS in …

[HTML][HTML] The hippocampal response to acute corticosterone elevation is altered in a mouse model for Angelman syndrome

…, B Distel, R Houtman, J Kroon, Y Elgersma… - International journal of …, 2022 - mdpi.com
Angelman Syndrome (AS) is a severe neurodevelopmental disorder, caused by the
neuronal absence of the ubiquitin protein ligase E3A (UBE3A). UBE3A promotes ubiquitin-mediated …

Modifying milk composition through forage

A Elgersma, S Tamminga, G Ellen - Animal feed science and technology, 2006 - Elsevier
The fatty acid (FA) composition of cows milk has become less favorable to human health in
the last four decades due to changed feeding and management practices, notably higher …