The incidence and mortality of small-cell lung cancer worldwide make this disease a notable
health-care issue. Diagnosis relies on histology, with the use of immunohistochemical …

… van Meerbeeck … van Meerbeeck … KH is supported in part by the Foundation Against Cancer,
a Belgian foundation of public interest; by the research grant Emmanuel Van der Schueren of …

Small cell lung cancer (SCLC) is an aggressive lung tumour strongly associated with cigarette
smoking, with patients often presenting with metastatic disease at the time of diagnosis. …

… van Meerbeeck , … van Meerbeeck … van Meerbeeck, Gijs WPM Kramer, Paul EY Van Schil,
Catherine Legrand, Egbert F. Smit, Franz Schramel, Vivianne C. Tjan-Heijnen, Bonne Biesma, …

Purpose We conducted a phase III trial to determine whether first-line treatment with
raltitrexed, a thymidine synthase inhibitor, and cisplatin results in superior outcome …

Context Mediastinal nodal staging is recommended for patients with resectable non–small
cell lung cancer (NSCLC). Surgical staging has limitations, which results in the performance …

Exosomes are membrane vesicles from endosomal origin secreted by various cells such as
hematopoietic, epithelial, and tumor cells. Exosomes secreted by tumor cells contain specific …

Background Concurrent chemoradiotherapy is the standard of care in limited-stage small-cell
lung cancer, but the optimal radiotherapy schedule and dose remains controversial. The …

PURPOSE:: Gemcitabine–platinum combination activity has been clearly established in a
number of phase II studies. It has also been compared against other combinations in many …

Background The current staging system for malignant pleural mesothelioma (MPM) is
controversial. To plan revisions of this system, the International Association for the Study of Lung …