During lung development, repair, and inflammation, local production of cytokines (eg,
transforming growth factor-β) and growth factors (eg, epidermal growth factor) by epithelial and …

The unpredictable and potentially lethal course of massive haemoptysis requires prompt
resuscitation, airway protection, and correction of coagulopathy. Early investigation with …

The aims of this article are to understand the shortfalls in thinking of asthma purely as an
atopic disorder, to gain insight into the epithelial abnormalities of asthma and how these …

Rationale: Incident pulmonary arterial hypertension was underrepresented in most pulmonary
hypertension registries and may have a different disease profile to prevalent disease. …

Background— Chronic thromboembolic pulmonary hypertension results from incomplete
resolution of pulmonary emboli. Pulmonary endarterectomy (PEA) is potentially curative, but …

Congenital or acquired cellular deficiencies in humans have the potential to reveal much
about normal hematopoiesis and immune function. We show that a recently described …

Abnormal apoptotic mechanisms are associated with disease pathogenesis. Because the
asthmatic bronchial epithelium is characteristically damaged with loss of columnar epithelial …

Long-term survival after lung transplantation remains limited by the development of bronchiolitis
obliterans syndrome (BOS). Allograft colonization with Pseudomonas aeruginosa is …

Interleukin (IL)-4 and IL-13 are key proinflammatory cytokines in asthma. Studies in transgenic
mice show that both cytokines cause inflammation, but only IL-13 causes subepithelial …

Pro-inflammatory and anti-inflammatory cytokines are important mediators in the host
response to infection. In contrast to the pro-inflammatory cytokines little is known about anti-…