The amount of radiologically dense breast-tissue appearing on a mammogram varies between
women because of differences in the composition of breast tissue, and is referred to here …

This article is the first in a series of seven that will provide an overview of central concepts
and topical issues in modern genetic epidemiology. In this article, we provide an overall …

Background Fibroglandular breast tissue appears dense on mammogram, whereas fat
appears nondense. It is unclear whether absolute or percentage dense area more strongly …

Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer,
but the average magnitude of these risks is uncertain and may depend on the context. …

Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …

Importance The clinical management ofBRCA1andBRCA2mutation carriers requires accurate,
prospective cancer risk estimates. Objectives To estimate age-specific risks of breast, …

… Tests of fit for outliers were performed after Hopper and Mathews (21): In no instance was
there evidence ofa poor fit. For each twin pair, at each location, it is assumed that BMD has a …

Background Germline loss-of-function mutations in PALB2 are known to confer a predisposition
to breast cancer. However, the lifetime risk of breast cancer that is conferred by such …

Prostate cancer is the most common cancer affecting males in developed countries. It shows
consistent evidence of familial aggregation, but the causes of this aggregation are mostly …

Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …