User profiles for J. L. Hopper
John L HopperUniversity of Melbourne Verified email at unimelb.edu.au Cited by 140289 |
Mammographic breast density as an intermediate phenotype for breast cancer
The amount of radiologically dense breast-tissue appearing on a mammogram varies between
women because of differences in the composition of breast tissue, and is referred to here …
women because of differences in the composition of breast tissue, and is referred to here …
Key concepts in genetic epidemiology
This article is the first in a series of seven that will provide an overview of central concepts
and topical issues in modern genetic epidemiology. In this article, we provide an overall …
and topical issues in modern genetic epidemiology. In this article, we provide an overall …
Mammographic density phenotypes and risk of breast cancer: a meta-analysis
…, G Hislop, AM Chiarelli, JL Hopper… - Journal of the …, 2014 - academic.oup.com
Background Fibroglandular breast tissue appears dense on mammogram, whereas fat
appears nondense. It is unclear whether absolute or percentage dense area more strongly …
appears nondense. It is unclear whether absolute or percentage dense area more strongly …
[PDF][PDF] Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined …
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer,
but the average magnitude of these risks is uncertain and may depend on the context. …
but the average magnitude of these risks is uncertain and may depend on the context. …
Genome-wide association study identifies novel breast cancer susceptibility loci
Breast cancer exhibits familial aggregation, consistent with variation in genetic susceptibility
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …
to the disease. Known susceptibility genes account for less than 25% of the familial risk of …
Risks of breast, ovarian, and contralateral breast cancer for BRCA1 and BRCA2 mutation carriers
Importance The clinical management ofBRCA1andBRCA2mutation carriers requires accurate,
prospective cancer risk estimates. Objectives To estimate age-specific risks of breast, …
prospective cancer risk estimates. Objectives To estimate age-specific risks of breast, …
Genetic determinants of bone mass in adults. A twin study.
… Tests of fit for outliers were performed after Hopper and Mathews (21): In no instance was
there evidence ofa poor fit. For each twin pair, at each location, it is assumed that BMD has a …
there evidence ofa poor fit. For each twin pair, at each location, it is assumed that BMD has a …
[HTML][HTML] Breast-Cancer Risk in Families with Mutations in PALB2
Background Germline loss-of-function mutations in PALB2 are known to confer a predisposition
to breast cancer. However, the lifetime risk of breast cancer that is conferred by such …
to breast cancer. However, the lifetime risk of breast cancer that is conferred by such …
Multiple newly identified loci associated with prostate cancer susceptibility
Prostate cancer is the most common cancer affecting males in developed countries. It shows
consistent evidence of familial aggregation, but the causes of this aggregation are mostly …
consistent evidence of familial aggregation, but the causes of this aggregation are mostly …
Association analysis identifies 65 new breast cancer risk loci
…, A Hollestelle, MJ Hooning, RN Hoover, JL Hopper… - Nature, 2017 - nature.com
Breast cancer risk is influenced by rare coding variants in susceptibility genes, such as
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …
BRCA1, and many common, mostly non-coding variants. However, much of the genetic …