The efficacy and safety of high-dose intravenous polyspecific immunoglobulin G (IVIG) as
adjunctive therapy in streptococcal toxic shock syndrome (STSS) were evaluated in a …

The past 2 decades have brought worrying increases in severe Streptococcus pyogenes
diseases globally. To investigate and compare the epidemiological patterns of these diseases …

In an attempt to compare the epidemiology of severe Streptococcus pyogenes infection within
Europe, prospective data were collected through the Strep-EURO program. Surveillance …

We sequenced the genomes of 3,615 strains of serotype Emm protein 1 (M1) group A
Streptococcus to unravel the nature and timing of molecular events contributing to the emergence, …

… In a prospective surveillance study of invasive GAS infections reported by Darenberg et
al [27], 75 STSS cases were identified for which additional clinical and therapeutic …

Immunotherapy targeted against microbial toxins and host mediators has been studied in
many preclinical investigations and clinical trials of sepsis during the past 20 y. Intravenous …

Background. The incidence and severity of invasive group A streptococcal infection
demonstrate great variability over time, which at least, in part, seems to be related to group A …

The effects of pneumococcal conjugated vaccines (PCVs) need to be investigated. In Stockholm
County, Sweden, PCV7 was introduced in the childhood immunisation programme in …

Background Pneumococccal conjugated pneumococcal vaccine (PCV10) and pneumococcal
conjugate vaccine 13 (PCV13), are used in childhood immunization programs worldwide, …

Administration of intravenous polyspecific immunoglobulin G (IVIG) has been proposed as
adjunctive therapy for toxic shock syndrome caused by Streptococcus pyogenes or …