Application of high-throughput screening techniques to drug discovery

B Cox, JC Denyer, A Binnie, MC Donnelly… - Progress in …, 2000 - books.google.com
B. COX ETAL. 85 rapid evolution in recent years with the advent of combinatorial chemistry,
new assay technologies, miniaturized formats and fully automated hardware platforms [1–6]. …

Pacemaking in rabbit isolated sino‐atrial node cells during Cs+ block of the hyperpolarization‐activated current if.

JC Denyer, HF Brown - The Journal of physiology, 1990 - Wiley Online Library
1. Experiments have been carried out using the whole‐cell patch clamp technique to investigate
how the spontaneous pacemaker activity of rabbit isolated sino‐atrial (SA) node cells is …

Reciprocal role of the inward currents ib, Na and if in controlling and stabilizing pacemaker frequency of rabbit sino-atrial node cells

D Noble, JC Denyer, HF Brown… - Proceedings of the …, 1992 - royalsocietypublishing.org
Experiments and computations were done to clarify the role of the various inward currents in
generating and modulating pacemaker frequency. Ionic currents in rabbit single isolated …

Rabbit sino‐atrial node cells: isolation and electrophysiological properties.

JC Denyer, HF Brown - The Journal of physiology, 1990 - Wiley Online Library
1. A method has been developed for isolating calcium‐tolerant, single rabbit sinoatrial node
cells which maintain their natural shape following isolation. The majority of viable, …

Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects

…, CL Ledbetter, MJ Hurle, JC Denyer… - European …, 2008 - Eur Respiratory Soc
Asthmatics, unlike healthy subjects, experience bronchoconstriction in response to inhaled
adenosine, and extracellular adenosine concentrations are elevated in the bronchoalveolar …

Pharmacological characterization of the αvβ6 integrin binding and internalization kinetics of the foot-and-mouth disease virus derived peptide A20FMDV2

…, JF Marshall, DJ Flint, S Pyne, JC Denyer - Pharmacology, 2016 - karger.com
A20FMDV2 is a peptide derived from the foot-and-mouth disease virus with a high affinity
and selectivity for the alpha-v beta-6 (αvβ6) arginyl-glycinyl-aspartic acid (RGD)-binding …

N-type calcium channel blockers in pain and stroke

B Cox, JC Denyer - Expert Opinion on Therapeutic Patents, 1998 - Taylor & Francis
N-type calcium channels are located at presynaptic termini throughout the central nervous
system (CNS), where they play a key role in the regulation of neurotransmitter release. In the …

Cardiac pacemaker activity: from single cells to modelling the heart

D Noble, JC Denyer, HF Brown, R Winslow… - Heart Function in Health …, 1993 - Springer
… In the Nobel-DiFrancesco-Denyer model we simply used the … This is also observed
experimentally (Denyer and Brown, … Denyer JC, Brown HF. A method for isolating rabbit sinoatrial …

[CITATION][C] Office management

JC Denyer - (No Title), 1980 - cir.nii.ac.jp
Denyer, JC … 責任表示 JC Denyer

Modelling of cardiac rhythm: from single cells to massive networks

D Noble, JC Denyer, HF Brown, R Winslow… - Coupled Oscillating …, 1992 - Springer
The development of models of the sinoatrial node cell is reviewed to show the steady
progress from the early models based on voltage clamp of small multicellular preparations to …