Application of high-throughput screening techniques to drug discovery
B Cox, JC Denyer, A Binnie, MC Donnelly… - Progress in …, 2000 - books.google.com
B. COX ETAL. 85 rapid evolution in recent years with the advent of combinatorial chemistry,
new assay technologies, miniaturized formats and fully automated hardware platforms [1–6]. …
new assay technologies, miniaturized formats and fully automated hardware platforms [1–6]. …
Pacemaking in rabbit isolated sino‐atrial node cells during Cs+ block of the hyperpolarization‐activated current if.
JC Denyer, HF Brown - The Journal of physiology, 1990 - Wiley Online Library
1. Experiments have been carried out using the whole‐cell patch clamp technique to investigate
how the spontaneous pacemaker activity of rabbit isolated sino‐atrial (SA) node cells is …
how the spontaneous pacemaker activity of rabbit isolated sino‐atrial (SA) node cells is …
Reciprocal role of the inward currents ib, Na and if in controlling and stabilizing pacemaker frequency of rabbit sino-atrial node cells
D Noble, JC Denyer, HF Brown… - Proceedings of the …, 1992 - royalsocietypublishing.org
Experiments and computations were done to clarify the role of the various inward currents in
generating and modulating pacemaker frequency. Ionic currents in rabbit single isolated …
generating and modulating pacemaker frequency. Ionic currents in rabbit single isolated …
Rabbit sino‐atrial node cells: isolation and electrophysiological properties.
JC Denyer, HF Brown - The Journal of physiology, 1990 - Wiley Online Library
1. A method has been developed for isolating calcium‐tolerant, single rabbit sinoatrial node
cells which maintain their natural shape following isolation. The majority of viable, …
cells which maintain their natural shape following isolation. The majority of viable, …
Elevated expression of adenosine A1 receptor in bronchial biopsy specimens from asthmatic subjects
…, CL Ledbetter, MJ Hurle, JC Denyer… - European …, 2008 - Eur Respiratory Soc
Asthmatics, unlike healthy subjects, experience bronchoconstriction in response to inhaled
adenosine, and extracellular adenosine concentrations are elevated in the bronchoalveolar …
adenosine, and extracellular adenosine concentrations are elevated in the bronchoalveolar …
Pharmacological characterization of the αvβ6 integrin binding and internalization kinetics of the foot-and-mouth disease virus derived peptide A20FMDV2
…, JF Marshall, DJ Flint, S Pyne, JC Denyer - Pharmacology, 2016 - karger.com
A20FMDV2 is a peptide derived from the foot-and-mouth disease virus with a high affinity
and selectivity for the alpha-v beta-6 (αvβ6) arginyl-glycinyl-aspartic acid (RGD)-binding …
and selectivity for the alpha-v beta-6 (αvβ6) arginyl-glycinyl-aspartic acid (RGD)-binding …
N-type calcium channel blockers in pain and stroke
B Cox, JC Denyer - Expert Opinion on Therapeutic Patents, 1998 - Taylor & Francis
N-type calcium channels are located at presynaptic termini throughout the central nervous
system (CNS), where they play a key role in the regulation of neurotransmitter release. In the …
system (CNS), where they play a key role in the regulation of neurotransmitter release. In the …
Cardiac pacemaker activity: from single cells to modelling the heart
… In the Nobel-DiFrancesco-Denyer model we simply used the … This is also observed
experimentally (Denyer and Brown, … Denyer JC, Brown HF. A method for isolating rabbit sinoatrial …
experimentally (Denyer and Brown, … Denyer JC, Brown HF. A method for isolating rabbit sinoatrial …
[CITATION][C] Office management
JC Denyer - (No Title), 1980 - cir.nii.ac.jp
… Denyer, JC … 責任表示 JC Denyer …
Modelling of cardiac rhythm: from single cells to massive networks
The development of models of the sinoatrial node cell is reviewed to show the steady
progress from the early models based on voltage clamp of small multicellular preparations to …
progress from the early models based on voltage clamp of small multicellular preparations to …