The natural history of idiopathic pulmonary fibrosis (IPF) has been characterized as a steady,
predictable decline in lung function over time. Recent evidence suggests that some …

Oxidative stress is an imbalance between oxidants (reactive oxygen and nitrogen species)
and antioxidants that may affect lipids, DNA, carbohydrates and proteins. The lung is …

Our understanding of the immunopathogenesis of sarcoidosis has been advanced by studies
of bronchoalveolar lavage cells. Activated macrophages and T-cells have been identified …

BIBF 1000 is a small molecule inhibitor targeting the receptor kinases of platelet-derived
growth factor (PDGF), basic fibroblast growth factor and vascular endothelial growth factor, …

… Ziegenhagen MW, Zabel P, Zissel G, Schlaak M, Müller-Quernheim J. Serum level of
interleukin 8 is elevated in idiopathic pulmonary fibrosis and indicates disease activity. Am …

Activated macrophages have been characterized as M1 and M2 according to their inflammatory
response pattern. Here we analyzed the M2 marker expression and intracellular signal …

… Ziegenhagen MW, Zabel P, Zissel G, Schlaak M, Müller-Quernheim J. Serum level of
interleukin 8 is elevated in idiopathic pulmonary fibrosis and indicates disease activity. Am …

Rationale: Evidence suggests that tumor necrosis factor (TNF)-α plays an important role in
the pathophysiology of sarcoidosis. Objectives: To assess the efficacy of infliximab in …

Sarcoidosis is a polygenic immune disorder with predominant manifestation in the lung.
Genome-wide linkage analysis previously indicated that the extended major histocompatibility …

In a few patients with chronic sarcoidosis, prolonged, unacceptably high doses of corticosteroids
are required to achieve symptomatic relief. In these cases, a corticosteroid-sparing drug …