User profiles for J Laitinen

Jaana Laitinen

Research Professor, Finnish Institute of Occupational Health
Verified email at ttl.fi
Cited by 36758

The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2‐arachidonoylglycerol signalling through cannabinoid receptors

JR Savinainen, SM Saario, JT Laitinen - Acta physiologica, 2012 - Wiley Online Library
The endocannabinoid 2‐arachidonoylglycerol (2‐AG) is a lipid mediator involved in various
physiological processes. In response to neural activity, 2‐AG is synthesized post‐…

Barriers to regular exercise among adults at high risk or diagnosed with type 2 diabetes: a systematic review

…, MA Alahuhta, JH Laitinen - Health promotion …, 2009 - academic.oup.com
The aim of this systematic review was to identify the reported barriers to regular exercise
among adults either at high risk or already diagnosed with type 2 diabetes (T2D), because of …

Genetic studies of body mass index yield new insights for obesity biology

…, W Koenig, M Koskenvuo, W Kratzer, J Laitinen… - Nature, 2015 - nature.com
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of
obesity better, here we conduct a genome-wide association study and Metabochip meta-…

Hundreds of variants clustered in genomic loci and biological pathways affect human height

…, I Kolcic, S Koskinen, P Kovacs, J Laitinen, J Liu… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

…, NRG Shrine, LV Wain, MA Morken, AJ Swift, J Laitinen… - Nature, 2011 - nature.com
Blood pressure is a heritable trait 1 influenced by several biological pathways and responsive
to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm …

Sequence variants at CHRNB3CHRNA6 and CYP2A6 affect smoking behavior

…, J Kettunen, AL Hartikainen, A Pouta, J Laitinen… - Nature …, 2010 - nature.com
Smoking is a common risk factor for many diseases 1 . We conducted genome-wide
association meta-analyses for the number of cigarettes smoked per day (CPD) in smokers (n = …

Genome-wide association analysis of metabolic traits in a birth cohort from a founder population

…, M Kaakinen, U Sovio, A Ruokonen, J Laitinen… - Nature …, 2009 - nature.com
Genome-wide association studies (GWAS) of longitudinal birth cohorts enable joint investigation
of environmental and genetic influences on complex traits. We report GWAS results for …

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

…, M Kumari, K Kuulasmaa, J Kuusisto, JH Laitinen… - Nature …, 2013 - nature.com
Approaches exploiting trait distribution extremes may be used to identify loci associated
with common traits, but it is unknown whether these loci are generalizable to the broader …

[HTML][HTML] Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution

…, P Jousilahti, F Karpe, J Kuusisto, J Laitinen… - PLoS …, 2009 - journals.plos.org
To identify genetic loci influencing central obesity and fat distribution, we performed a meta-analysis
of 16 genome-wide association studies (GWAS, N = 38,580) informative for adult …

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

…, P Elliott, S Hadjadj, MR Jaervelin, J Laitinen… - Nature …, 2009 - nature.com
Genome-wide association studies have identified common variants that only partially explain
the genetic risk for type 2 diabetes (T2D). Using genome-wide association data from 1,376 …