User profiles for J Brugues

Jan Brugues

Professor at Physics of Life, TU Dresden
Verified email at tu-dresden.de
Cited by 1930

Costs of asthma according to the degree of severity

…, E Morejon, A Comella, J Brugues - European …, 1998 - Eur Respiratory Soc
An increase in asthma-related morbidity and mortality has been reported recently, resulting
in a substantial increase in the economic impact of this condition. Little information is …

The physics of the metaphase spindle

…, DJ Needleman, J Brugués - Annual review of …, 2018 - annualreviews.org
The assembly of the mitotic spindle and the subsequent segregation of sister chromatids
are based on the self-organized action of microtubule filaments, motor proteins, and other …

Cohesin and condensin extrude DNA loops in a cell cycle-dependent manner

S Golfier, T Quail, H Kimura, J Brugués - Elife, 2020 - elifesciences.org
Loop extrusion by structural maintenance of chromosomes (SMC) complexes has been
proposed as a mechanism to organize chromatin in interphase and metaphase. However, the …

Physical basis of spindle self-organization

J Brugués, D Needleman - Proceedings of the National …, 2014 - National Acad Sciences
The cytoskeleton forms a variety of steady-state, subcellular structures that are maintained by
continuous fluxes of molecules and energy. Understanding such self-organizing structures …

[HTML][HTML] C. elegans chromosomes connect to centrosomes by anchoring into the spindle network

…, E Nazockdast, A Kratz, S Prohaska, J Brugués… - Nature …, 2017 - nature.com
The mitotic spindle ensures the faithful segregation of chromosomes. Here we combine the
first large-scale serial electron tomography of whole mitotic spindles in early C. elegans …

Dynamic instability of the intracellular pressure drives bleb-based motility

B Maugis, J Brugués, P Nassoy… - Journal of cell …, 2010 - journals.biologists.com
We have demonstrated that the two- and three-dimensional motility of the human pathogenic
parasite Entamoeba histolytica (Eh) depends on sustained instability of the intracellular …

Newton-Hooke algebras, nonrelativistic branes, and generalized pp-wave metrics

J Brugués, J Gomis, K Kamimura - Physical Review D, 2006 - APS
… Jan Brugués … where T is the nonrelativistic p-brane tension and j j 0;1;... ;p are the
parameters of the worldvolume. p 1 is given by … where e j is the inverse of the p …

Autocatalytic microtubule nucleation determines the size and mass of Xenopus laevis egg extract spindles

F Decker, D Oriola, B Dalton, J Brugues - Elife, 2018 - elifesciences.org
… We also thank J Rosenberger for helping on the coding for laser ablation. We kindly thank
R Ohi and K Ishihara for providing us the anti-MCAK antibodies and RanQ69L, respectively. …

[HTML][HTML] Non-relativistic strings and branes as non-linear realizations of Galilei groups

J Brugues, T Curtright, J Gomis, L Mezincescu - Physics Letters B, 2004 - Elsevier
… Applying the general techniques for non-linear realizations of spacetime symmetries, as in
[9], we consider the coset element (4) g= exp (−itH+ixP) exp iX a P a +iv b K b +iθ c J c , where …

[PDF][PDF] Model for probing membrane-cortex adhesion by micropipette aspiration and fluctuation spectroscopy

R Alert, J Casademunt, J Brugués, P Sens - Biophysical journal, 2015 - cell.com
We propose a model for membrane-cortex adhesion that couples membrane deformations,
hydrodynamics, and kinetics of membrane-cortex ligands. In its simplest form, the model …