New naphtho/thienobenzo-triazoles with interconnected anti-inflammatory and cholinesterase inhibitory activity

M Mlakić, I Odak, I Faraho, S Talić, M Bosnar… - European journal of …, 2022 - Elsevier
New 1,2,3-triazolo(thieno)stilbenes were synthesized by Wittig reaction and photochemically
transformed to corresponding substituted thienobenzo/naphtho-triazoles in high isolated …

Precision-cut lung slices from bleomycin treated animals as a model for testing potential therapies for idiopathic pulmonary fibrosis

…, D Belamarić, AP Radičević, I Faraho… - Pulmonary …, 2019 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a complex lung disease with incompletely understood
pathophysiology. Effectiveness of available medicines is limited and the need for new and …

Synthesis, photochemistry and computational study of novel 1, 2, 3-triazole heterostilbenes: Expressed biological activity of their electrocyclization photoproducts

M Mlakić, I Faraho, I Odak, S Talić, A Vukovinski… - Bioorganic …, 2022 - Elsevier
New 1,2,3-triazolostilbenes were synthesized and photochemically transformed to substituted
naphthotriazoles as electrocyclization products in high isolated yields for studying the …

Design, synthesis and biological evaluation of new 1, 3-thiazole derivatives as potential anti-inflammatory agents

M Modrić, M Božičević, I Faraho, M Bosnar… - Journal of molecular …, 2021 - Elsevier
Thiazoles are widely recognized as nuclei of great value for obtaining molecules with various
biological activities, including analgesic, anti-inflammatory, anti-HIV, antidiabetic, antitumor …

[HTML][HTML] Synthesis, photochemistry, computational study and potential application of new styryl-thiophene and naphtho-thiophene benzylamines

M Mlakić, I Odak, I Faraho, M Bosnar… - International journal of …, 2022 - mdpi.com
In this research, the synthesis, photochemistry, and computational study of new cis- and
trans-isomers of amino-thienostilbenes is performed to test the efficiency of their production and …

[HTML][HTML] Anti-inflammatory activity of lefamulin versus azithromycin and dexamethasone in vivo and in vitro in a lipopolysaccharide-induced lung neutrophilia mouse …

…, S Paukner, WW Wicha, B Hrvačić, M Cedilak, I Faraho… - Plos one, 2021 - journals.plos.org
Several antibiotics demonstrate both antibacterial and anti-inflammatory/immunomodulatory
activities and are used to treat inflammatory pulmonary disorders. Lefamulin is a …

[HTML][HTML] Cholinesterase Inhibitory and Anti-Inflammatory Activity of the Naphtho-and Thienobenzo-Triazole Photoproducts: Experimental and Computational Study

M Mlakić, I Faraho, I Odak, B Kovačević… - International journal of …, 2023 - mdpi.com
New 1,2,3-triazolo(thieno)stilbenes were synthesized as mixtures of isomers and efficiently
photochemically transformed to their corresponding substituted thienobenzo/naphtho-…

Correlation of ex vivo cytokine secretion profiles with scoring indices in ulcerative colitis

M Podolski, L Požgaj, I Faraho… - European Journal of …, 2023 - Wiley Online Library
Background In ulcerative colitis, the complexity of mucosal cytokine secretion profiles and
how they correlate with endoscopic and clinical scores is still unclear. Methods In this study, …

[HTML][HTML] Favipiravir in patients hospitalised with COVID-19 (PIONEER trial): a multicentre, open-label, phase 3, randomised controlled trial of early intervention versus …

…, S Hughes, W Zhe, A De Leon, A Farah… - The Lancet …, 2023 - thelancet.com
Background COVID-19 has overwhelmed health services globally. Oral antiviral therapies
are licensed worldwide, but indications and efficacy rates vary. We aimed to evaluate the …

Histopathologic features predictive of metastasis and survival in 230 patients with cutaneous squamous cell carcinoma of the head and neck and non‐head and neck …

M Farah, DR Milton, ND Gross… - Journal of the …, 2022 - Wiley Online Library
Background Staging systems for cutaneous squamous cell carcinoma (cSCC) produce
inconsistent risk stratification. Objective The aim of this study was to identify further prognostic …