Cluster of differentiation 24 (CD24) is a small, highly glycosylated cell adhesion protein that
is normally expressed by immune as well as epithelial, neural, and muscle cells. Tumor …

Tumor dormancy refers to a critical stage of cancer development when tumor cells are present,
but cancer does not progress. It includes both the concept of cellular dormancy, indicating …

Antibodies play a crucial role in basic research and clinical decision-making. However, there
are no standardized algorithms or guidelines to ensure their accuracy and validity. There …

PKM2 phosphorylation marks aggressive breast cancer cell phenotypes and targeting
PKM2pS37 could be an effective therapeutic approach for treating triple-negative breast cancer. …

Original research: Spatially resolved proteomic profiling identifies tumor cell CD44 as a
biomarker associated with sensitivity to PD-1 axis blockade in advanced non-small-cell lung …

Background The prognostic value of tumor-infiltrating lymphocytes (TILs) assessed by machine
learning algorithms in melanoma patients has been previously demonstrated but has not …

Ki67, a nuclear proliferation-related protein, is heavily used in anatomic pathology but has
not become a companion diagnostic or a standard-of-care biomarker due to analytic …

Assessment of programmed cell death-ligand 1 (PD-L1) expression by immunohistochemistry
(IHC) is the definite diagnostic test to guide treatment for patients with advanced-stage non…

Background: There is an increasing number of liver injury cases resembling autoimmune
hepatitis (AIH) following SARS-CoV-2 vaccination; however, an association has not yet been …

Introduction Despite the clinical efficacy of immune checkpoint inhibitors (ICIs) in NSCLC, only
approximately 20% of patients remain disease-free at 5 years. Here, we use digital spatial …