User profiles for Inke König

Inke König

Professorin für Medizinische Biometrie und Statistik
Verified email at uni-luebeck.de
Cited by 43782

Overview of random forest methodology and practical guidance with emphasis on computational biology and bioinformatics

…, S Janitza, J Kruppa, IR König - … Reviews: Data Mining …, 2012 - Wiley Online Library
The random forest (RF) algorithm by Leo Breiman has become a standard data analysis
tool in bioinformatics. It has shown excellent performance in settings where the number of …

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

…, P Linsel-Nitschke, W Lieb, A Ziegler, IR König… - Nature …, 2009 - nature.com
We conducted a genome-wide association study testing single nucleotide polymorphisms (SNPs)
and copy number variants (CNVs) for association with early-onset myocardial …

What is precision medicine?

IR König, O Fuchs, G Hansen… - European respiratory …, 2017 - Eur Respiratory Soc
The term “precision medicine” has become very popular over recent years, fuelled by scientific
as well as political perspectives. Despite its popularity, its exact meaning, and how it is …

Biological, clinical and population relevance of 95 loci for blood lipids

…, R Laaksonen, KO Kyvik, F Kronenberg, IR König… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …

[HTML][HTML] Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

…, J Erdmann, P Diemert, C Willenborg, IR König… - The Lancet, 2012 - thelancet.com
Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Large-scale association analysis identifies new risk loci for coronary artery disease

…, J Erdmann, BA Goldstein, K Stirrups, IR König… - Nature …, 2013 - nature.com
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an
association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching …

Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants

M Dichgans, R Malik, IR König, J Rosand, R Clarke… - Stroke, 2014 - Am Heart Assoc
Background and Purpose— Ischemic stroke (IS) and coronary artery disease (CAD) share
several risk factors and each has a substantial heritability. We conducted a genome-wide …

[HTML][HTML] Genomewide association analysis of coronary artery disease

…, HE Wichmann, JH Barrett, IR König… - … England Journal of …, 2007 - Mass Medical Soc
Background Modern genotyping platforms permit a systematic search for inherited components
of complex diseases. We performed a joint analysis of two genomewide association …

Hundreds of variants clustered in genomic loci and biological pathways affect human height

…, M Juhani Junttila, LM Kaplan, J Kettunen, IR König… - Nature, 2010 - nature.com
Most common human traits and diseases have a polygenic pattern of inheritance: DNA
sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA…

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

H Schunkert, IR König, S Kathiresan, MP Reilly… - Nature …, 2011 - nature.com
We performed a meta-analysis of 14 genome-wide association studies of coronary artery
disease (CAD) comprising 22,233 individuals with CAD (cases) and 64,762 controls of …