We recently reported that mast cells stimulated via FcεRI aggregation can enhance T cell
activation by a TNF-dependent mechanism. However, the molecular mechanisms responsible …

IL-33 is a recently identified member of the IL-1 family of molecules, which also includes IL-1
and IL-18. IL-33 binds to the receptor, T1/ST2/IL-1R4, and can promote cytokine secretion …

Basophils are thought to play pivotal roles in allergic inflammation through rapid release of
chemical mediators in addition to sustained production of Th2 cytokines, including IL-4. A …

The IL-1-related molecules, IL-1 and IL-18, can promote Th2 cytokine production by IgE/antigen-FcεRI-stimulated
mouse mast cells. Another IL-1-related molecule, IL-33, was identified …

House dust mite-derived proteases contribute to allergic disorders in part by disrupting
epithelial barrier function. Interleukin-33 (IL-33), produced by lung cells after exposure to …

Introduction The prevalence of asthma, chronic obstructive pulmonary disease (COPD), and
asthma-COPD overlap (ACO) in patients with COVID-19 varies, as well as their risks of …

Eosinophils are important effector cells in allergic diseases, but the mechanisms regulating
their biological functions remain obscure. Interleukin-33 (IL-33) is a recently identified …

BACKGROUND: Mast cells, IgE, and TNF, which have been implicated in human atopic
asthma, contribute significantly to the allergic airway inflammation induced by ovalbumin (OVA) …

Members of the T-cell immunoglobulin– and mucin-domain–containing molecule (TIM)
family have roles in T-cell–mediated immune responses. TIM-1 and TIM-2 are predominantly …

Background Viral infection is one of the risk factors for asthma exacerbation. However, which
pathogens are related to asthma exacerbation in adults remains unclear. Objective The …