User profiles for Igor Jurisica
Igor JurisicaVerified email at ai.utoronto.ca Cited by 38218 |
High-throughput mapping of a dynamic signaling network in mammalian cells
Signaling pathways transmit information through protein interaction networks that are
dynamically regulated by complex extracellular cues. We developed LUMIER (for luminescence-…
dynamically regulated by complex extracellular cues. We developed LUMIER (for luminescence-…
Isolation of single human hematopoietic stem cells capable of long-term multilineage engraftment
Lifelong blood cell production is dependent on rare hematopoietic stem cells (HSCs) to
perpetually replenish mature cells via a series of lineage-restricted intermediates. Investigating …
perpetually replenish mature cells via a series of lineage-restricted intermediates. Investigating …
Protein interaction data curation: the International Molecular Exchange (IMEx) consortium
The International Molecular Exchange (IMEx) consortium is an international collaboration
between major public interaction data providers to share literature-curation efforts and make a …
between major public interaction data providers to share literature-curation efforts and make a …
Stem cell gene expression programs influence clinical outcome in human leukemia
…, C Buske, MD Minden, TR Golub, I Jurisica… - Nature medicine, 2011 - nature.com
Xenograft studies indicate that some solid tumors and leukemias are organized as cellular
hierarchies sustained by cancer stem cells (CSCs). Despite the promise of the CSC model, its …
hierarchies sustained by cancer stem cells (CSCs). Despite the promise of the CSC model, its …
Modeling interactome: scale-free or geometric?
N Pržulj, DG Corneil, I Jurisica - Bioinformatics, 2004 - academic.oup.com
Motivation: Networks have been used to model many real-world phenomena to better
understand the phenomena and to guide experiments in order to predict their behavior. Since …
understand the phenomena and to guide experiments in order to predict their behavior. Since …
Protein complex prediction via cost-based clustering
Motivation: Understanding principles of cellular organization and function can be enhanced
if we detect known and predict still undiscovered protein complexes within the cell's protein–…
if we detect known and predict still undiscovered protein complexes within the cell's protein–…
Comprehensive molecular profiling of lung adenocarcinoma: The cancer genome atlas research network
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we
report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, …
report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, …
Online predicted human interaction database
KR Brown, I Jurisica - Bioinformatics, 2005 - academic.oup.com
Motivation: High-throughput experiments are being performed at an ever-increasing rate to
systematically elucidate protein–protein interaction (PPI) networks for model organisms, …
systematically elucidate protein–protein interaction (PPI) networks for model organisms, …
The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis
…, SK Lau, PC Boutros, F Khosravi, I Jurisica… - Cancer research, 2006 - AACR
The product of the MYC oncogene is widely deregulated in cancer and functions as a regulator
of gene transcription. Despite an extensive profile of regulated genes, the transcriptional …
of gene transcription. Despite an extensive profile of regulated genes, the transcriptional …
Functional topology in a network of protein interactions
Motivation: The building blocks of biological networks are individual protein–protein interactions
(PPIs). The cumulative PPI data set in Saccharomyces cerevisiae now exceeds 78 000. …
(PPIs). The cumulative PPI data set in Saccharomyces cerevisiae now exceeds 78 000. …