Purpose. We have used rhDNase to investigate the feasibility of developing a dry protein
powder aerosol for inhalation delivery. Methods. Powders of rhDNase alone and with sodium …

The origins of inhalation therapy can be traced back to the early civilizations but this route of
administration was relatively uncommon until recently. Direct delivery of drugs to the lung by …

No marketed inhaled products currently use sustained release formulations such as liposomes
to enhance drug disposition in the lung, but that may soon change. This review focuses …

The effect of nebulizer solution temperature and dilution air humidity on the size and solute
concentration of aqueous aerosol droplets were studied. Four combinations of jet-nebulizers …

Except for management of Pseudomonas aeruginosa (PA) in cystic fibrosis, there are no
approved inhaled antibiotic treatments for any other diseases or for infections from other …

Excessive heat and water losses from the airways are stimuli to asthma. To study heat and
water vapor transport in the human respiratory tract, a time-dependent model, based on a …

Unwanted systemic absorption of drugs delivered for the local treatment of respiratory
disease is well documented. Methods to minimize this now exist, especially for reduction of …

We developed a bronchial provocation test (BPT) with a dry powder preparation of mannitol.
The mannitol was inhaled from gelatin capsules containing 5, 10, 20, or 40 mg to a …

The coronavirus disease 2019 (COVID-19) is an unprecedented pandemic that has severely
impacted global public health and the economy. Hydroxychloroquine administered orally to …

Background The delivery of antipseudomonal antibiotics by inhalation to Pseudomonas
aeruginosa-infected subjects with non-cystic fibrosis (CF) bronchiectasis is a logical extension of …