[HTML][HTML] The role of cancer-associated fibroblasts, solid stress and other microenvironmental factors in tumor progression and therapy resistance

G Kharaishvili, D Simkova, K Bouchalova… - Cancer cell …, 2014 - Springer
Tumors are not merely masses of neoplastic cells but complex tissues composed of cellular
and noncellular elements. This review provides recent data on the main components of a …

Shifting the limits in wheat research and breeding using a fully annotated reference genome

…, KFX Mayer, D Ormanbekova, V Prade, H Šimková… - Science, 2018 - science.org
INTRODUCTION Wheat (Triticum aestivum L.) is the most widely cultivated crop on Earth,
contributing about a fifth of the total calories consumed by humans. Consequently, wheat …

A chromosome-based draft sequence of the hexaploid bread wheat (Triticum aestivum) genome

…, Z Dubská, J Vrana, R Šperková, H Šimková… - Science, 2014 - science.org
An ordered draft sequence of the 17-gigabase hexaploid bread wheat (Triticum aestivum)
genome has been produced by sequencing isolated chromosome arms. We have annotated …

Chronic thromboembolic pulmonary hypertension (CTEPH) results from an international prospective registry

…, A Torbicki, B Kristensen, J Lewczuk, I Simkova… - Circulation, 2011 - Am Heart Assoc
Background— Chronic thromboembolic pulmonary hypertension (CTEPH) is often a sequel
of venous thromboembolism with fatal natural history; however, many cases can be cured by …

Long-term outcome of patients with chronic thromboembolic pulmonary hypertension: results from an international prospective registry

…, A Torbicki, S Mellemkjaer, J Lewczuk, I Simkova… - Circulation, 2016 - Am Heart Assoc
Background— Chronic thromboembolic pulmonary hypertension, a rare complication of acute
pulmonary embolism, is characterized by fibrothrombotic obstructions of large pulmonary …

[HTML][HTML] Lumasiran, an RNAi therapeutic for primary hyperoxaluria type 1

…, SH Moochhala, G Schalk, E Simkova… - New England journal …, 2021 - Mass Medical Soc
Background Primary hyperoxaluria type 1 (PH1) is a rare genetic disease caused by hepatic
overproduction of oxalate that leads to kidney stones, nephrocalcinosis, kidney failure, and …

A physical map of the 1-gigabase bread wheat chromosome 3B

…, H Bergès, K Eversole, R Appels, J Safar, H Simkova… - science, 2008 - science.org
As the staple food for 35% of the world's population, wheat is one of the most important crop
species. To date, sequence-based tools to accelerate wheat improvement are lacking. As …

Recessive mutations in DGKE cause atypical hemolytic-uremic syndrome

…, B Llanas, L Collard, MA Majid, E Simkova… - Nature …, 2013 - nature.com
Pathologic thrombosis is a major cause of mortality. Hemolytic-uremic syndrome (HUS)
features episodes of small-vessel thrombosis resulting in microangiopathic hemolytic anemia, …

Investigating patterns may reveal processes: evolutionary ecology of ectoparasitic monogeneans

S Morand, A Simková, I Matejusová, L Plaisance… - International Journal for …, 2002 - Elsevier
We reviewed several published and ongoing studies concerning monogenean communities.
Patterns of species richness, host specificity, community structure and host–parasite …

[HTML][HTML] Insula activity in resting-state differentiates bipolar from unipolar depression: a systematic review and meta-analysis

M Pastrnak, E Simkova, T Novak - Scientific reports, 2021 - nature.com
Symptomatic overlap of depressive episodes in bipolar disorder (BD) and major depressive
disorder (MDD) is a major diagnostic and therapeutic problem. Mania in medical history …