Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms

G Kleinau, G Krause - Endocrine reviews, 2009 - academic.oup.com
The TSH receptor (TSHR) together with the homologous lutropin/choriogonadotropin receptor
and the follitropin receptor are glycoprotein hormone receptors (GPHRs). They constitute …

Novel insights on thyroid-stimulating hormone receptor signal transduction

G Kleinau, S Neumann, A Grüters, H Krude… - Endocrine …, 2013 - academic.oup.com
The TSH receptor (TSHR) is a member of the glycoprotein hormone receptors, a subfamily
of family AG protein-coupled receptors. The TSHR is of great importance for the growth and …

[HTML][HTML] Marginal zone B cells: from housekeeping function to autoimmunity?

AKE Palm, S Kleinau - Journal of Autoimmunity, 2021 - Elsevier
Marginal zone (MZ) B cells comprise a subset of innate-like B cells found predominantly in
the spleen, but also in lymph nodes and blood. Their principal functions are participation in …

Induction and suppression of collagen-induced arthritis is dependent on distinct Fcγ receptors

S Kleinau, P Martinsson, B Heyman - The Journal of experimental …, 2000 - rupress.org
Receptors for immunoglobulin (Ig)G (FcγRs) are important for the antibody-mediated effector
functions of the immune system. FcγRI and FcγRIII trigger cell activation through a common …

MC4R agonism promotes durable weight loss in patients with leptin receptor deficiency

…, L Puder, F Fiedorek, K Gottesdiener, G Kleinau… - Nature medicine, 2018 - nature.com
Genetic defects underlying the melanocortin-4 receptor (MC4R) signaling pathway lead to
severe obesity. Three severely obese LEPR-deficient individuals were administered the …

High-resolution in-plane investigation of the water evolution and transport in PEM fuel cells

C Hartnig, I Manke, R Kuhn, S Kleinau… - Journal of Power …, 2009 - Elsevier
High-resolution synchrotron X-ray radiography is used to study the evolution of primary water
clusters and the transport of liquid water from the catalyst layer through the gas diffusion …

Complement deficiency ameliorates collagen-induced arthritis in mice

…, IM Jonsson, A Tarkowski, S Kleinau… - The Journal of …, 2002 - journals.aai.org
Collagen-induced arthritis (CIA) is an experimental animal model of human rheumatoid arthritis
being characterized by synovitis and progressive destruction of cartilage and bone. CIA …

Induction of arthritis by single monoclonal IgG anti‐collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcγRIIB

…, S Hellström, R Holmdahl, S Kleinau - European journal of …, 2003 - Wiley Online Library
IgG anti‐collagen type II (CII) antibodies (Ab) can induce arthritis in healthy mice. Here we
have investigated if single monoclonal IgG anti‐CII Ab can induce arthritis in CIA‐susceptible …

Routinely adding ultrasound examinations by pocket-sized ultrasound devices improves inpatient diagnostics in a medical department

OC Mjolstad, H Dalen, T Graven, JO Kleinau… - European Journal of …, 2012 - Elsevier
BACKGROUND: We aimed to investigate the potential benefit of adding a routine cardiac and
abdominal diagnostic examination by pocket-sized ultrasound device in patients admitted …

[HTML][HTML] Introducing the Open Energy Ontology: Enhancing data interpretation and interfacing in energy systems analysis

…, C Hofmann, C Hoyer-Klick, L Hülk, A Kleinau… - Energy and AI, 2021 - Elsevier
Heterogeneous data, different definitions and incompatible models are a huge problem in
many domains, with no exception for the field of energy systems analysis. Hence, it is hard to …