The L-type α 1C (Ca v 1.2) calcium channel is the major calcium entry pathway in cardiac and
smooth muscle. We inactivated theCa v 1.2 gene in two independent mouse lines that had …

Over the past few decades, research on Alzheimer’s disease (AD) has focused on pathomechanisms
linked to two of the major pathological hallmarks of extracellular deposition of beta-…

To study the role of cGMP-dependent protein kinase I (cGKI) for cardiac contractility, force of
contraction (F c ) was studied in electrically driven heart muscle from wild-type (WT) mice …

Introduction. Though Staphylococcus aureus is a major pathogen, vaccine trials have failed.
In contrast, class-switched antibodies specific to S. aureus are common, implying immune …

Neutrophil elastase (NE) is a key risk factor for severity of cystic fibrosis (CF) lung disease.
Recent studies identified increased NE activity on the surface of airway neutrophils from CF-…

Previous in vitro studies using cGMP or cAMP revealed a cross-talk between signaling
mechanisms activated by axonal guidance receptors. However, the molecular elements …

Teachers' emotional competence predicts teachers' mental health and the teacher-student
relationship. Therefore, training pre-service teachers' emotional competence seems important…

The cGMP-dependent protein kinase type I (cGKI) is a major mediator of NO/cGMP-induced
vasorelaxation. Smooth muscle expresses two isoforms of cGKI, cGKIα and cGKIβ, but the …

p8 is a stress-induced DNA-binding protein, biochemically related to the architectural
chromatin binding HMG protein family and whose function is presently unknown. We obtained …

The surface of insects is covered by a complex mixture of cuticular hydrocarbons (CHCs) to
prevent desiccation. In many species these lipids also have communicative functions, but …