Activated platelets enhance microparticle formation and platelet-leukocyte interaction in severe trauma and sepsis

…, T Koh, R Tanaka, Y Ozeki, H Hosotsubo… - Journal of Trauma …, 2001 - journals.lww.com
Background Activated platelets have been recently reported to produce platelet microparticles
and to enhance platelet-leukocyte interaction. The precise role of platelets in systemic …

[HTML][HTML] Presence of neutrophil extracellular traps and citrullinated histone H3 in the bloodstream of critically ill patients

…, T Irisawa, M Seki, O Tasaki, H Hosotsubo… - PloS one, 2014 - journals.plos.org
Neutrophil extracellular traps (NETs), a newly identified immune mechanism, are induced by
inflammatory stimuli. Modification by citrullination of histone H3 is thought to be involved in …

Priming, second-hit priming, and apoptosis in leukocytes from trauma patients

…, N Hashiguchi, Y Kuwagata, H Hosotsubo… - Journal of Trauma …, 1999 - journals.lww.com
Background Polymorphonuclear leukocytes (PMNL) play important roles in both host
defenses and systemic inflammatory responses after insults. The objectives of this study are to …

Synbiotics decrease the incidence of septic complications in patients with severe SIRS: a preliminary report

…, A Matsushima, O Tasaki, K Fujita, H Hosotsubo… - Digestive diseases and …, 2009 - Springer
The purpose of this study was to evaluate if synbiotic therapy can correct the deteriorated gut
flora and environment in patients with severe systemic inflammatory response syndrome (…

Enhanced production of endothelial microparticles with increased binding to leukocytes in patients with severe systemic inflammatory response syndrome

…, S Fujimi, Y Nakamori, H Hosotsubo… - Journal of Trauma …, 2004 - journals.lww.com
Background: The vascular endothelium sustains substantial damage after severe insult.
Recently, activated endothelial cells have been reported to produce microparticles in vitro. The …

Systemic involvement of high-mobility group box 1 protein and therapeutic effect of anti–high-mobility group box 1 protein antibody in a rat model of crush injury

…, J Nakagawa, K Yamakawa, H Hosotsubo… - Shock, 2012 - journals.lww.com
Patients with crush injury often present systemic inflammatory response syndrome and fall
into multiple organ failure. The mechanism by which the local tissue damage induces distant …

Activated polymorphonuclear leukocytes enhance production of leukocyte microparticles with increased adhesion molecules in patients with sepsis

…, H Ogura, H Tanaka, T Koh, H Hosotsubo… - Journal of Trauma …, 2002 - journals.lww.com
Background Leukocyte microparticles (MPs) derived from polymorphonuclear leukocytes (PMNLs)
have been recently found to be activators of vascular endothelium in vitro. The …

Early activation of γδ T lymphocytes in patients with severe systemic inflammatory response syndrome

…, T Koh, H Tanaka, Y Sumi, K Yoshiya, H Hosotsubo… - Shock, 2004 - journals.lww.com
Innate immunity plays an important role in host defense after severe insult. γδ T lymphocytes
are recognized as the first line of defense against microbial invasion. In this study, we …

New experimental model of crush injury of the hindlimbs in rats

P Akimau, K Yoshiya, H Hosotsubo… - Journal of Trauma …, 2005 - journals.lww.com
Background: Crush injury (CI) remains a life-threatening condition. Because there is a shortage
of animal models of CI, we purposed to develop a reproducible model of CI of hindlimbs …

Identification of neutrophil extracellular traps in the blood of patients with systemic inflammatory response syndrome

…, T Irisawa, M Seki, H Hosotsubo… - Journal of …, 2013 - journals.sagepub.com
Objective Neutrophils are able to form ‘neutrophil extracellular traps’ (NETs), which they use
to trap and kill pathogens such as bacteria and fungi at the foci of infection. This …