In mammals, the master clock of the suprachiasmatic nuclei (SCN) and subordinate clocks
found throughout the body coordinate circadian rhythms of behavior and physiology. We …

Adrenal glucocorticoids are major modulators of multiple functions, including energy
metabolism, stress responses, immunity, and cognition. The endogenous secretion of …

Shiftwork is associated with adverse metabolic pathophysiology, and the rising incidence of
shiftwork in modern societies is thought to contribute to the worldwide increase in obesity …

In mammals, a network of circadian clocks regulates 24-h rhythms of behavior and
physiology. Circadian disruption promotes obesity and the development of obesity-associated …

Jet lag encompasses a range of psycho- and physiopathological symptoms that arise from
temporal misalignment of the endogenous circadian clock with external time. Repeated jet lag …

Lymphocytes circulate through lymph nodes (LN) in search for antigen in what is believed to
be a continuous process. Here, we show that lymphocyte migration through lymph nodes …

Several studies suggest a link between circadian rhythm disturbances and tumorigenesis.
However, the association between circadian clock genes and prognosis in breast cancer has …

Human and animal studies demonstrate that short sleep or poor sleep quality, eg in night
shift workers, promote the development of obesity and diabetes. Effects of sleep disruption on …

Regulation of body temperature critically depends on thyroid hormone (TH). Recent studies
revealed that TH induces browning of white adipose tissue, possibly contributing to the …

Perturbation of circadian rhythmicity in mammals, either by environmental influences such as
shiftwork or by genetic manipulation, has been associated with metabolic disturbance and …