User profiles for Henrik Knecht

Henrik Knecht

Verified email at med2.uni-kiel.de
Cited by 2051

Gut microbiota disturbance during antibiotic therapy: a multi-omic approach

AE Pérez-Cobas, MJ Gosalbes, A Friedrichs, H Knecht… - Gut, 2013 - gut.bmj.com
Objective Antibiotic (AB) usage strongly affects microbial intestinal metabolism and thereby
impacts human health. Understanding this process and the underlying mechanisms remains …

[HTML][HTML] Differential effects of antibiotic therapy on the structure and function of human gut microbiota

AE Pérez-Cobas, A Artacho, H Knecht, ML Ferrus… - PloS one, 2013 - journals.plos.org
The human intestinal microbiota performs many essential functions for the host. Antimicrobial
agents, such as antibiotics (AB), are also known to disturb microbial community equilibrium…

[HTML][HTML] Standardized next-generation sequencing of immunoglobulin and T-cell receptor gene recombinations for MRD marker identification in acute lymphoblastic …

M Brüggemann, M Kotrova, H Knecht, J Bartram… - Leukemia, 2019 - nature.com
Amplicon-based next-generation sequencing (NGS) of immunoglobulin (IG) and T-cell
receptor (TR) gene rearrangements for clonality assessment, marker identification and …

[HTML][HTML] Effects of probiotics and antibiotics on the intestinal homeostasis in a computer controlled model of the large intestine

…, FA Heinsen, ME Koenen, K Venema, H Knecht… - BMC microbiology, 2012 - Springer
Background Antibiotic associated diarrhea and Clostridium difficile infection are frequent
complications of broad spectrum antibiotic therapy. Probiotic bacteria are used as therapeutic …

ARResT/Interrogate: an interactive immunoprofiler for IG/TR NGS data

…, M Demko, B Hanakova, A Grioni, H Knecht… - …, 2017 - academic.oup.com
Motivation The study of immunoglobulins and T cell receptors using next-generation
sequencing has finally allowed exploring immune repertoires and responses in their immense …

Functional consequences of microbial shifts in the human gastrointestinal tract linked to antibiotic treatment and obesity

…, AE Pérez-Cobas, MJ Gosalbes, H Knecht… - Gut …, 2013 - Taylor & Francis
The microbiomes in the gastrointestinal tract (GIT) of individuals receiving antibiotics and
those in obese subjects undergo compositional shifts, the metabolic effects and linkages of …

[HTML][HTML] Quality control and quantification in IG/TR next-generation sequencing marker identification: protocols and bioinformatic functionalities by EuroClonality-NGS

H Knecht, T Reigl, M Kotrová, F Appelt, P Stewart… - Leukemia, 2019 - nature.com
Assessment of clonality, marker identification and measurement of minimal residual disease
(MRD) of immunoglobulin (IG) and T cell receptor (TR) gene rearrangements in lymphoid …

[HTML][HTML] Effects of β-Lactam Antibiotics and Fluoroquinolones on Human Gut Microbiota in Relation to Clostridium difficile Associated Diarrhea

H Knecht, SC Neulinger, FA Heinsen, C Knecht… - PloS one, 2014 - journals.plos.org
Clostridium difficile infections are an emerging health problem in the modern hospital
environment. Severe alterations of the gut microbiome with loss of resistance to colonization …

Temperature‐driven shifts in the epibiotic bacterial community composition of the brown macroalga Fucus vesiculosus

SB Stratil, SC Neulinger, H Knecht… - …, 2013 - Wiley Online Library
The thallus surface of the brown macroalga F ucus vesiculosus is covered by a specific
biofilm community. This biofilm supposedly plays an important role in the interaction between …

Dynamic changes of the luminal and mucosa-associated gut microbiota during and after antibiotic therapy with paromomycin

…, H Knecht, SC Neulinger, RA Schmitz, C Knecht… - Gut …, 2015 - Taylor & Francis
Gut microbiota play a key role in the host's health system. Broad antibiotic therapy is known
to disrupt the microbial balance affecting pathogenic as well as host-associated microbes. …