Despite the beneficial effects of pirfenidone in treating idiopathic pulmonary fibrosis (IPF), it
remains unclear if lung fibroblasts (FB) are the main therapeutic target. To resolve this …

In idiopathic pulmonary arterial hypertension (IPAH), global transcriptional changes induce
a smooth muscle cell phenotype characterised by excessive proliferation, migration, and …

The extracellular matrix (ECM) increasingly emerges as an active driver in several diseases,
including idiopathic pulmonary arterial hypertension (IPAH). The basement membrane (BM) …

A central feature of progressive vascular remodeling is altered smooth muscle cell (SMC)
homeostasis; however, the understanding of how different cell populations contribute to this …

The exposure of mouse embryos in utero and primary cortical neurons to ionizing radiation
results in the P53-dependent activation of a subset of genes that is highly induced during …

Within the pulmonary arterial tree, the NOTCH3 pathway is crucial in controlling vascular
smooth muscle cell proliferation and maintaining smooth muscle cells in an undifferentiated …

Excess and ectopic smooth muscle cells (SMCs) are central to cardiovascular disease
pathogenesis, but underlying mechanisms are poorly defined. For instance, pulmonary …

Acute cardiorespiratory responses to O 2 deficiency are essential for physiological homeostasis.
The prototypical acute O 2 -sensing organ is the carotid body, which contains glomus …

METHODS: Basement-membrane ultrastructure was visualized via electron microscopy.
Gene-expression was evaluated on laser-capture microdissected pulmonary arteries. Plasma …