Bioreactor technology is vital for tissue engineering. Usually, bioreactors are used to provide
a tissue‐specific physiological in vitro environment during tissue maturation. In addition to …

In vitro models of the human blood-brain barrier (BBB) are highly desirable for drug development.
This study aims to analyze a set of ten different BBB culture models based on primary …

In this study we used differentiated adult human upcyte ® cells for the in vitro generation of
liver organoids. Upcyte ® cells are genetically engineered cell strains derived from primary …

A chip-based system mimicking the transport function of the human cardiovascular system
has been established at minute but standardized microsystem scale. A peristaltic on-chip …

For the development of new treatment strategies against cancer, understanding signaling
networks and their changes upon drug response is a promising approach to identify new drug …

Cancer is one of the leading causes of death worldwide. Current therapeutic strategies are
predominantly developed in 2D culture systems, which inadequately reflect physiological …

Various factors, including the phylogenetic distance between laboratory animals and humans,
the discrepancy between current in vitro systems and the human body, and the restrictions …

Solid tumors impose immunologic and physical barriers to the efficacy of chimeric antigen
receptor (CAR) T cell therapy that are not reflected in conventional preclinical testing against …

Models of the outer epithelia of the human body - namely the skin, the intestine and the lung
- have found valid applications in both research and industrial settings as attractive …

Our focus was to develop a three-dimensional (3D) human dynamic in vitro tissue model
that mimics the natural microenvironment of the small intestine. We co-cultured human Caco-2 …