The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. We have
recently demonstrated the presence of about six cycling Lgr5 + stem cells at the bottoms of …

The intestinal epithelium is the most rapidly self-renewing tissue in adult mammals. It is currently
believed that four to six crypt stem cells reside at the +4 position immediately above the …

Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells
to exhibit their remarkable self-organizing properties, and the resulting organoids reflect …

A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal
transduction cascade over the last two decades. Wnt genes encode small secreted proteins that …

Homeostasis of self-renewing small intestinal crypts results from neutral competition between
Lgr5 stem cells, which are small cycling cells located at crypt bottoms 1 , 2 . Lgr5 stem cells …

BACKGROUND & AIMS: We previously established long-term culture conditions under which
single crypts or stem cells derived from mouse small intestine expand over long periods. …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause coronavirus
disease 2019 (COVID-19), an influenza-like disease that is primarily thought to infect the lungs …

The canonical Wnt cascade has emerged as a critical regulator of stem cells. In many tissues,
activation of Wnt signalling has also been associated with cancer. This has raised the …

Intestinal cancer is initiated by Wnt-pathway-activating mutations in genes such as adenomatous
polyposis coli (APC). As in most cancers, the cell of origin has remained elusive. In a …

The adult stem cell marker Lgr5 and its relative Lgr4 are often co-expressed in Wnt-driven
proliferative compartments. We find that conditional deletion of both genes in the mouse gut …