The vast majority of acute heart failure episodes are characterized by increasing symptoms
and signs of congestion with volume overload. The goal of therapy in those patients is the …

Organ injury and impairment are commonly observed in patients with acute heart failure (AHF),
and congestion is an essential pathophysiological mechanism of impaired organ function…

Aims Natriuretic peptide-guided (NP-guided) treatment of heart failure has been tested against
standard clinically guided care in multiple studies, but findings have been limited by study …

Background Sodium–glucose cotransporter 2 inhibitors reduce the risk of hospitalization for
heart failure in patients with heart failure and a reduced ejection fraction, but their effects in …

Background Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce the risk of hospitalization
for heart failure in patients regardless of the presence or absence of diabetes. More …

Objectives : We sought to define the incidence of late clinical events and late stent thrombosis
in patients treated with drug-eluting (DES) versus bare-metal stents (BMS) after the …

Background Cardiac muscle hypercontractility is a key pathophysiological abnormality in
hypertrophic cardiomyopathy, and a major determinant of dynamic left ventricular outflow tract (…

… Author Contributions: Drs Pfisterer and Brunner-La Rocca had full access to all of the data
in the study and take responsibility for the integrity of the data and the accuracy of the data …

… Brunner-La Rocca, professor of cardiology,5 Willem van Mechelen, professor of occupational
and sports medicine,6 Jardena J Puder, assistant professor of endocrinology, diabetes …

Objective Two hypotheses concerning mechanisms of weight gain and of blood pressure
elevation in obesity were tested. The first hypothesis is that in human obesity sympathetic …