It is widely accepted that the development of carcinoma — the most common form of human
cancer — is due to the accumulation of somatic mutations in epithelial cells. The behaviour …

Transforming growth factor-β (TGFβ) signalling regulates cancer through mechanisms that
function either within the tumour cell itself or through host–tumour cell interactions. Studies of …

… The D factor induces differentiation of the human promyelocytic leukemia cell line HL-60 (216);
chemical treatment of HL-60 cells leads to an induction of the c-fms proto-oncogene (205…

Pancreatic ductal adenocarcinoma (PDAC) is associated with marked fibrosis and stromal
myofibroblasts, but their functional contribution remains unknown. Transgenic mice with the …

Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia.
The role of transforming growth factor–β (TGF-β) signaling in such epithelial-mesenchymal …

Transforming growth factor beta (TGF-beta) is a potent chemoattractant in vitro for human
dermal fibroblasts. Intact disulfide and perhaps the dimeric structure of TGF-beta is essential for …

… However, repeated freezing and thawing appeared to result in so'me degree of activation
(Lyons, RM, and HL Moses, unpublished data). Therefore, untreated conditioned medium was …

Triple-negative breast cancer (TNBC) is a heterogeneous disease that can be classified into
distinct molecular subtypes by gene expression profiling. Considered a difficult-to-treat …

… Each of the lines selected for further studies were TGF-β sensitive for growth inhibition and
EMT (Bhowmick and Moses, unpublished data). NMuMG cells were infected with virus by …

Transforming growth factor β (TGF-β) plays an important role in tumor initiation and progression,
functioning as both a suppressor and a promoter. The mechanisms underlying this dual …