SARS-CoV-2 productively infects human gut enterocytes

…, J Paul van Schayck, AZ Mykytyn, HQ Duimel… - Science, 2020 - science.org
… membrane vesicles (DMVs) [(E), asterisk], initial viral production in the Golgi apparatus [(F)
and (G)], and complete occupation of virus particles inside the endomembrane system (H). (I …

Antibody effector mechanisms in myasthenia gravis—pathogenesis at the neuromuscular junction

…, MAM Lemmens, E Van Der Esch, H Duimel… - …, 2010 - Taylor & Francis
Myasthenia gravis (MG) is an autoimmune disorder caused by autoantibodies that are
either directed to the muscle nicotinic acetylcholine receptor (AChR) or to the muscle-specific …

[HTML][HTML] Fixation methods for electron microscopy of human and other liver

E Wisse, F Braet, H Duimel, C Vreuls… - World journal of …, 2010 - ncbi.nlm.nih.gov
… Therefore, it is recommended to have the animals about 2 h before the surgical procedure
within the operating room to accustom them to the environment and reduce the level of stress. …

[PDF][PDF] Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

…, PJ van Gorp, V Bieghs, MJ Gijbels, H Duimel… - …, 2008 - Wiley Online Library
Nonalcoholic steatohepatitis (NASH) involves liver lipid accumulation (steatosis) combined
with hepatic inflammation. The transition towards hepatic inflammation represents a key step …

Thin-walled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions: relevance of compromised structural integrity for …

…, K Maxfield, E Pacheco, B Kutys, H Duimel… - Journal of the American …, 2009 - jacc.org
Objectives : This study sought to examine the ultrastructure of microvessels in normal and
atherosclerotic coronary arteries and its association with plaque phenotype. Background : …

An organoid‐derived bronchioalveolar model for SARS‐CoV‐2 infection of human alveolar type II‐like cells

…, N Groen, RBG Ravelli, HQ Duimel… - The EMBO …, 2021 - embopress.org
… , 48, and 72 h after infection at MOI 0.1. Cultures were either pretreated with 50 ng/ml IFN
lambda 1 in the basal compartment 2 h prior to the infection (green), at 24 h pi or left untreated. …

Time course of atrial fibrillation-induced cellular structural remodeling in atria of the goat

J Ausma, N Litjens, MH Lenders, H Duimel… - Journal of molecular and …, 2001 - Elsevier
… 1 h, dehydrated through graded ethanol series and routinely embedded in epoxy resin
Epon… (h) Slender elongated mitochondria with longitudinally oriented cristae (arrow), also …

Reduced mitochondrial density in the vastus lateralis muscle of patients with COPD

HR Gosker, MKC Hesselink, H Duimel… - European …, 2007 - Eur Respiratory Soc
Skeletal muscle dysfunction is a well-recognised hallmark of chronic obstructive pulmonary
disease (COPD) leading to exercise intolerance. The vastus lateralis of COPD patients is …

[HTML][HTML] The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria

…, G Schaart, M Losen, MH De Baets, H Duimel… - Histochemistry and cell …, 2012 - Springer
Perilipin 5 (PLIN5/OXPAT) is a lipid droplet (LD) coat protein mainly present in tissues with
a high fat-oxidative capacity, suggesting a role for PLIN5 in facilitating fatty acid oxidation. …

[HTML][HTML] Effects of ethanol and acetaldehyde on tight junction integrity: in vitro study in a three dimensional intestinal epithelial cell culture model

…, S van IJzendoorn, F Troost, H Duimel… - PloS one, 2012 - journals.plos.org
… Exposure to ethanol (10–40 mM) or acetaldehyde (25–200 µM) for 3 h, dose-dependently
and additively increased the paracellular permeability and induced redistribution of ZO-1 and …