The importance of genetic influences in asthma

H Los, GH Koppelman… - European Respiratory …, 1999 - Eur Respiratory Soc
Asthma is a complex genetic disorder in which the mode of inheritance is not known. Many
segregation studies suggest that a major gene could be involved in asthma, but until now …

Asthma genetics and intermediate phenotypes: a review from twin studies

H Los, PE Postmus, DI Boomsma - Twin Research and Human …, 2001 - cambridge.org
It has been long recognised that asthma and related phenoypes have an important hereditary
nature, in which inheritance does not follow the classical Mendelian patterns and the exact …

Genetic and environment in asthma: the answer of twin studies

GH Koppelman, H Los… - European Respiratory …, 1999 - Eur Respiratory Soc
Twin studies have been widely used to estimate the genetic contribution to diseases. In this
issue of the European Respiratory Journal, SKADHAUGE et al.[1] present the results of a …

Predicting the consequences of nutrient reduction on the eutrophication status of the North Sea

…, M Blaas, X Desmit, W Kühn, G Lacroix, HJ Los… - Journal of Marine …, 2010 - Elsevier
… , dew point temperature, 2 m temperature, 10 mu and v wind components, total cloud cover)
on a N80 spherical grid with a spatial resolution of 1.125 × 1.125 horizontal grid in 6 h time-…

Fuzzy modeling of cyanobacterial surface waterblooms: validation with NOAA‐AVHRR satellite images

BW Ibelings, M Vonk, HFJ Los… - Ecological …, 2003 - Wiley Online Library
… For appearance of blooms, the mean wind speed during the last hour (m/s), the cumulative
flux of solar irradiance over the past 6 h (J·cm −2 ·6 h −1 ), and the time of day were taken into …

[HTML][HTML] GEM: a generic ecological model for estuaries and coastal waters

AN Blauw, HFJ Los, M Bokhorst, PLA Erftemeijer - Hydrobiologia, 2009 - Springer
… , transport and a small number of processes are simulated with a short time step (ie 30 min
of less), while the majority of processes are simulated using a much longer time step of 24 h. …

Eelgrass seed dispersal via floating generative shoots in the Dutch Wadden Sea: a model approach

…, JKL van Beek, CA Ochieng, Z Jager, HJ Los - Marine Ecology …, 2008 - int-res.com
Potential long-distance dispersal of eelgrass seeds via floating generative shoots from a
256 ha meadow in the Ems Estuary (Wadden Sea) was studied by means of computer-…

Impact of climatic fluctuations on Characeae biomass in a shallow, restored lake in The Netherlands

WJ Rip, MRL Ouboter, HJ Los - Shallow Lakes in a Changing World …, 2007 - Springer
… production based on competition among algal species (Los & Brinkman, 1988; Los, 2005).
The primary state variables of … Los, FJ, 2005. An algal biomass prediction model. In Daniel, P. …

Inhibition effects of nitrogen compounds on the hydrodesulfurization of dibenzothiophene

GC Laredo S, JA De los Reyes H, J Luis Cano D… - Applied Catalysis A …, 2001 - Elsevier
… , K H 2 S and K H are the adsorption equilibrium constants of DBT, hydrogen sulfide and
hydrogen, and C DBT , C H 2 S and C H … conditions, K H C H ⪢1 and the inhibition due to H 2 S …

In vitro generation of human pluripotent stem cell derived lung organoids

BR Dye, DR Hill, MAH Ferguson, YH Tsai, MS Nagy… - elife, 2015 - elifesciences.org
HLOs possess upper airway-like epithelium with basal cells and … that HLOs are remarkably
similar to human fetal lung based on global transcriptional profiles, suggesting that HLOs are …